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Effect of myeloid specific Trem2 knockout in hepatocellular carcinoma after anti-PD-1 therapy

GSE291235 Mus musculus Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing 30 samples Submitted 2026/04/29 Platform GPL21103Platform GPL24247
SuperSeries — this record groups several sub-series.
Summary
This SuperSeries is composed of the SubSeries listed below.
Published in
Tumor cells metabolically resist immune-checkpoint therapy by macrophage efferocytosis-mediated fatty acid recycling
Liang Z, Long X, Xiong Z et al. · Cancer cell 2026 · PMID 42259249 · doi:10.1016/j.ccell.2026.05.005
This dataset
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Direct links to NCBI, no account and no request form: the whole study as GSE291235_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 30 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1232627. Searching any of these in the dataset finder brings you back here.

Study design
10 conditions, mostly in triplicate
Liver tumor, Cre_PD1, ×3 Liver tumor, MKO_PD1, ×3 Liver tumor, Cre_PD1, H3K36ac ×3 Liver tumor, Cre_PD1, Input ×3 Liver tumor, MKO_PD1, H3K36ac ×3 Liver tumor, MKO_PD1, Input ×3 BMDM, without AC treatment, ×3 BMDM, with AC treatment, ×3 +2 more

Supports a between-group comparison across 30 samples.

10 replicated groups read from 30 sample titles; they account for 30 of them. Check it against the sample list below before relying on it.

Samples in this study
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