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H3K9 di-methylation dynamics underlies mouse minor zygotic genome activation

GSE296994 Mus musculus Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing 174 samples Submitted 2026/04/19 Platform GPL19057Platform GPL13112Platform GPL24247Platform GPL34290
SuperSeries — this record groups several sub-series.
Summary
This SuperSeries is composed of the SubSeries listed below.
Published in
Dynamic regulation of H3K9 dimethylation drives mouse minor zygotic genome activation
Maeda R, Kuroki S, Shimojo H et al. · Nature structural & molecular biology 2026 · PMID 42191875 · doi:10.1038/s41594-026-01811-w
This dataset
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Direct links to NCBI, no account and no request form: the whole study as GSE296994_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 174 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1262331 and SRA study SRP584851. Searching any of these in the dataset finder brings you back here.

Study design
20 conditions, mostly in duplicate
E2C_Input ×2 E2C_H3K9me2 ×2 Morula_Input ×2 Morula_H3K9me2 ×2 RNA_E2C_control ×2 RNA_E2C_Kdm3ab-mDKO ×2 RNA_MII_control ×2 RNA_MII_Kdm3ab-mDKO ×2 +12 more

Supports a between-group comparison across 40 samples.

20 replicated groups read from the first 40 of 174 sample titles; they account for 40 of them. Check it against the sample list below before relying on it.

Samples in this study

+ 134 more — browse all 174 samples with per-sample file links →

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