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H3K79 methylation and H3K36 trimethylation synergistically regulate gene expression in pluripotent stem cells

GSE292289 Mus musculus Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing 94 samples Submitted 2025/07/04 Platform GPL34328
SuperSeries — this record groups several sub-series.
Summary
This SuperSeries is composed of the SubSeries listed below.
Published in
H3K79 methylation and H3K36 trimethylation synergistically regulate gene expression in pluripotent stem cells
Cooke EW, Zeng C, Nur SM et al. · Science advances 2025 · PMID 40614207 · doi:10.1126/sciadv.adt8765
This dataset
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Direct links to NCBI, no account and no request form: the whole study as GSE292289_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 94 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1237820 and SRA study SRP571388. Searching any of these in the dataset finder brings you back here.

Study design
16 conditions, mostly in duplicate
WT_DMSO_72h_RNA ×4 WT_RNA ×3 DOT1LCI_RNA ×3 SETD2CI_RNA ×3 DCI_RNA ×3 WT_neural_day21_RNA ×3 DCI_neural_day21_RNA ×3 DCI_DMSO8h_RNA ×2 +8 more

Supports a between-group comparison across 40 samples.

16 replicated groups read from the first 40 of 94 sample titles; they account for 40 of them. Check it against the sample list below before relying on it.

Samples in this study

+ 54 more — browse all 94 samples with per-sample file links →

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