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The placentalia specific histone H3.4 promotes germ cell development and reproductive fitness

GSE291274 Mus musculus Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing 167 samples Submitted 2026/04/05 Platform GPL24247Platform GPL17021
SuperSeries — this record groups several sub-series.
Summary
This SuperSeries is composed of the SubSeries listed below.
Published in
The eutherian-specific histone H3.4 promotes germ cell development and reproductive fitness
Komarov PA, Bammer PC, Liang CY et al. · Nature communications 2026 · PMID 42248887 · doi:10.1038/s41467-026-73954-9
This dataset
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Direct links to NCBI, no account and no request form: the whole study as GSE291274_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 167 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1232694 and SRA study SRP568412. Searching any of these in the dataset finder brings you back here.

Study design
12 conditions, mostly in duplicate
SgU_wt_H3.3 ×2 SgU_tg_H3.3 ×2 SgU_tg_Myc ×2 SgD_wt_H3.3 ×2 SgD_tg_H3.3 ×2 SgD_tg_Myc ×2 ScLZ_wt_H3.3 ×2 ScLZ_tg_H3.3 ×2 +20 more

Supports a between-group comparison across 24 samples.

12 replicated groups read from the first 40 of 167 sample titles; they account for 24 of them. Check it against the sample list below before relying on it.

Samples in this study

+ 127 more — browse all 167 samples with per-sample file links →

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