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eIF4G2-mediated Translation Initiation of Histone Modifiers is Essential for Intestinal Stem Cell Maintenance and Differentiation

GSE318069 Mus musculus Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing 145 samples Submitted 2026/04/30 Platform GPL34290Platform GPL30172Platform GPL24247
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Summary
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This dataset
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Direct links to NCBI, no account and no request form: the whole study as GSE318069_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 145 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1416414 and SRA study SRP578610. Searching any of these in the dataset finder brings you back here.

Study design
10 conditions, mostly with about 4 replicates each
Heterozygous, Crypt, ×5 Homozygous, Villi, ×5 Heterozygous, Villi, ×5 Homozygous, Crypt, ×4 DMSO treated, ×4 3uM A-485 treated, ×4 5uM A-485 treated, ×4 flox/flox, ENR, DMSO, ×3 +2 more

Supports a case/control comparison: 11 samples read as cases, 3 as controls.

10 replicated groups read from the first 40 of 145 sample titles; they account for 40 of them. Check it against the sample list below before relying on it.

Samples in this study

+ 105 more — browse all 145 samples with per-sample file links →

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