GEO series
Lactate and histone H3K18 lactylation are associated with metabolic control of gene expression in the retina
GSE291677
Mus musculus
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
38 samples
Submitted 2026/02/26
Platform GPL30172
SuperSeries — this record groups several sub-series.
Summary
This SuperSeries is composed of the SubSeries listed below.
Published in
Gaur M, Brooks MJ, Liang X et al.
· PLoS genetics 2026
· PMID 41950290
· doi:10.1371/journal.pgen.1012100
This dataset
Download
Direct links to NCBI, no account and no request form: the whole study as GSE291677_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 38 samples. Raw sequencing reads are also available from ENA.
Also filed as BioProject PRJNA1234637 and SRA study SRP569640. Searching any of these in the dataset finder brings you back here.
Study design
15 conditions, mostly in duplicate
control, RNA-seq, ×5
2-DG, RNA-seq, ×4
5mM glucose, H3K18La (CUT&Tag), ×3
25mM glucose, H3K18La (CUT&Tag), ×3
P28 retina, H3K18La (CUT&Tag), ×3
5mM glucose, RNA-seq, biological replicate 1,… ×2
5mM glucose, RNA-seq, biological replicate 2,… ×2
5mM glucose, RNA-seq, biological replicate 3,… ×2
+7 more
Supports a between-group comparison across 38 samples.
15 replicated groups read from 38 sample titles; they account for 38 of them. Check it against the sample list below before relying on it.
Samples in this study
0 selected
- GSM8839498 5mM glucose, RNA-seq, biological replicate 1, technical replicate 1
- GSM8839499 5mM glucose, RNA-seq, biological replicate 1, technical replicate 2
- GSM8839500 5mM glucose, RNA-seq, biological replicate 2, technical replicate 1
- GSM8839501 5mM glucose, RNA-seq, biological replicate 2, technical replicate 2
- GSM8839502 5mM glucose, RNA-seq, biological replicate 3, technical replicate 1
- GSM8839503 5mM glucose, RNA-seq, biological replicate 3, technical replicate 2
- GSM8839504 25mM glucose, RNA-seq, biological replicate 1, technical replicate 1
- GSM8839505 25mM glucose, RNA-seq, biological replicate 1, technical replicate 2
- GSM8839506 25mM glucose, RNA-seq, biological replicate 2, technical replicate 1
- GSM8839507 25mM glucose, RNA-seq, biological replicate 2, technical replicate 2
- GSM8839508 25mM glucose, RNA-seq, biological replicate 3, technical replicate 1
- GSM8839509 25mM glucose, RNA-seq, biological replicate 3, technical replicate 2
- GSM8839516 5mM glucose, H3K18La (CUT&Tag), replicate 1
- GSM8839517 5mM glucose, H3K18La (CUT&Tag), replicate 2
- GSM8839518 5mM glucose, H3K18La (CUT&Tag), replicate 3
- GSM8839519 25mM glucose, H3K18La (CUT&Tag), replicate 1
- GSM8839520 25mM glucose, H3K18La (CUT&Tag), replicate 2
- GSM8839521 25mM glucose, H3K18La (CUT&Tag), replicate 3
- GSM8839522 5mM glucose, H3K27Ac (CUT&Tag), replicate 1
- GSM8839523 5mM glucose, H3K27Ac (CUT&Tag), replicate 2
- GSM8839524 25mM glucose, H3K27Ac (CUT&Tag), replicate 1
- GSM8839525 25mM glucose, H3K27Ac (CUT&Tag), replicate 2
- GSM8839526 P4 retina, H3K18La (CUT&Tag), replicate 1
- GSM8839527 P4 retina, H3K18La (CUT&Tag), replicate 2
- GSM8839528 P10 retina, H3K18La (CUT&Tag), replicate 1
- GSM8839529 P10 retina, H3K18La (CUT&Tag), replicate 2
- GSM8839530 P28 retina, H3K18La (CUT&Tag), replicate 1
- GSM8839531 P28 retina, H3K18La (CUT&Tag), replicate 2
- GSM8839532 P28 retina, H3K18La (CUT&Tag), replicate 3
- GSM9552605 control, RNA-seq, biological replicate 1
- GSM9552606 control, RNA-seq, biological replicate 2
- GSM9552607 control, RNA-seq, biological replicate 3
- GSM9552608 control, RNA-seq, biological replicate 4
- GSM9552609 control, RNA-seq, biological replicate 5
- GSM9552610 2-DG, RNA-seq, biological replicate 1
- GSM9552611 2-DG, RNA-seq, biological replicate 2
- GSM9552612 2-DG, RNA-seq, biological replicate 3
- GSM9552613 2-DG, RNA-seq, biological replicate 4
Similar datasets
- GSE291274 The placentalia specific histone H3.4 promotes germ cell development and reproductive fitness 167 samples
- GSE318069 eIF4G2-mediated Translation Initiation of Histone Modifiers is Essential for Intestinal Stem Cell Maintenance and Differentiation 145 samples
- GSE341379 Distinct histone 3 lysine methylation states underlie tumor immune surveillance 50 samples
- GSE246033 Histone serotonylation regulates ependymoma tumorigenesis through neurodevelopmental pathways 34 samples
- GSE239480 The Role of TCF7L2 in Hepatic Metabolic Zonation 12 samples
- GSE218984 Decreased expression of EZH2 in granulosa cells contributes to endometriosis-associated infertility by targeting IL-1R2 11 samples
- GSE217664 Decoding Trp53 regulatory program in various tissues and organs 404 samples
- GSE296994 H3K9 di-methylation dynamics underlies mouse minor zygotic genome activation 174 samples
Share this dataset
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.