GEO series
A conserved epithelial wound-like transcriptional program driven by FOSL1 underlies malignant progression of pancreatic ductal adenocarcinoma
GSE248586
Mus musculus
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
57 samples
Submitted 2026/04/30
Platform GPL24247Platform GPL28330Platform GPL21273
SuperSeries — this record groups several sub-series.
Summary
This SuperSeries is composed of the SubSeries listed below.
This dataset
Download
Direct links to NCBI, no account and no request form: the whole study as GSE248586_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 57 samples. Raw sequencing reads are also available from ENA.
Also filed as BioProject PRJNA1044813 and SRA study SRP474047. Searching any of these in the dataset finder brings you back here.
Study design
10 conditions, mostly in triplicate
Pdx1_KrasG12D, PanIN, Biological replicate1-T… ×3
Pdx1_KrasG12D, PanIN, Biological replicate2-T… ×3
Pdx1_KrasG12D, PanIN, Biological replicate3-T… ×3
Pdx1_KrasG12D_Trp53fl/fl, PDAC, Biological re… ×3
Ptf1a-CreERT2_KrasG12D, OE tBFP, Biological r… ×3
Ptf1a-CreERT2_KrasG12D, OE tBFP, Biological r… ×3
Ptf1a-CreERT2_KrasG12D, OE FOSL1_tBFP, Biolog… ×3
Ptf1a-CreERT2_KrasG12D, OE FOSL1_tBFP, Biolog… ×3
+14 more
Supports a between-group comparison across 28 samples.
10 replicated groups read from the first 40 of 57 sample titles; they account for 28 of them. Check it against the sample list below before relying on it.
Samples in this study
0 selected
- GSM7917401 Pdx1_KrasG12D_PanIN_R2_ATAC-seq_biol rep 1
- GSM7917402 Pdx1_KrasG12D_PanIN_R3_ATAC-seq_biol rep 2
- GSM7917403 Ptf1a-CreERT2_KrasG12D_OE tBFP_R1_ATAC-seq_biol rep 1
- GSM7917404 Ptf1a-CreERT2_KrasG12D_OE tBFP_R2_ATAC-seq_biol rep 2
- GSM7917405 Ptf1a-CreERT2_KrasG12D_OE FOSL1_tBFP_R1_ATAC-seq_biol rep 1
- GSM7917406 Ptf1a-CreERT2_KrasG12D_OE FOSL1_tBFP_R2_ATAC-seq_biol rep 2
- GSM7917407 pancreas, PanIN, scRNA-seq
- GSM7917408 pancreas, PDAC_TO_KrasG12D_KOTSGs_on_KrasG12D, scRNA-seq
- GSM7917409 pancreas, PDAC_TO_KrasG12D_KOTSGs_off_KrasG12D_3days, scRNA-seq
- GSM7917410 pancreas, PDAC_TO_KrasG12D_KOTSGs_off_KrasG12D_5days, scRNA-seq
- GSM7917411 pancreas, PDAC_KOTSGs, scRNA-seq
- GSM7917412 Pdx1_KrasG12D, PanIN, Biological replicate1-Technical replicate 1
- GSM7917413 Pdx1_KrasG12D, PanIN, Biological replicate1-Technical replicate 2
- GSM7917414 Pdx1_KrasG12D, PanIN, Biological replicate1-Technical replicate 3
- GSM7917415 Pdx1_KrasG12D, PanIN, Biological replicate2-Technical replicate 1
- GSM7917416 Pdx1_KrasG12D, PanIN, Biological replicate2-Technical replicate 2
- GSM7917417 Pdx1_KrasG12D, PanIN, Biological replicate2-Technical replicate 3
- GSM7917418 Pdx1_KrasG12D, PanIN, Biological replicate3-Technical replicate 1
- GSM7917419 Pdx1_KrasG12D, PanIN, Biological replicate3-Technical replicate 2
- GSM7917420 Pdx1_KrasG12D, PanIN, Biological replicate3-Technical replicate 3
- GSM7917421 Pdx1_KrasG12D_Trp53fl/fl, PDAC, Biological replicate1-Technical replicate 1
- GSM7917422 Pdx1_KrasG12D_Trp53fl/fl, PDAC, Biological replicate1-Technical replicate 2
- GSM7917423 Pdx1_KrasG12D_Trp53fl/fl, PDAC, Biological replicate1-Technical replicate 3
- GSM7917424 Pdx1_KrasG12D_Trp53fl/fl, PDAC, Biological replicate2-Technical replicate 1
- GSM7917425 Pdx1_KrasG12D_Trp53fl/fl, PDAC, Biological replicate2-Technical replicate 2
- GSM7917426 Pdx1_KrasG12D_Trp53fl/fl, PDAC, Biological replicate3-Technical replicate 1
- GSM7917427 Pdx1_KrasG12D_Trp53fl/fl, PDAC, Biological replicate3-Technical replicate 2
- GSM7917428 Ptf1a-CreERT2_KrasG12D, OE tBFP, Biological replicate1-Technical replicate 1
- GSM7917429 Ptf1a-CreERT2_KrasG12D, OE tBFP, Biological replicate1-Technical replicate 2
- GSM7917430 Ptf1a-CreERT2_KrasG12D, OE tBFP, Biological replicate1-Technical replicate 3
- GSM7917431 Ptf1a-CreERT2_KrasG12D, OE tBFP, Biological replicate2-Technical replicate 1
- GSM7917432 Ptf1a-CreERT2_KrasG12D, OE tBFP, Biological replicate2-Technical replicate 2
- GSM7917433 Ptf1a-CreERT2_KrasG12D, OE tBFP, Biological replicate2-Technical replicate 3
- GSM7917434 Ptf1a-CreERT2_KrasG12D, OE FOSL1_tBFP, Biological replicate1-Technical replicate 1
- GSM7917435 Ptf1a-CreERT2_KrasG12D, OE FOSL1_tBFP, Biological replicate1-Technical replicate 2
- GSM7917436 Ptf1a-CreERT2_KrasG12D, OE FOSL1_tBFP, Biological replicate1-Technical replicate 3
- GSM7917437 Ptf1a-CreERT2_KrasG12D, OE FOSL1_tBFP, Biological replicate2-Technical replicate 1
- GSM7917438 Ptf1a-CreERT2_KrasG12D, OE FOSL1_tBFP, Biological replicate2-Technical replicate 2
- GSM7917439 Ptf1a-CreERT2_KrasG12D, OE FOSL1_tBFP, Biological replicate2-Technical replicate 3
- GSM7917440 Pdx1-Cre_LSL-Cas9_LSL-rtTA, TO-KrasG12D-KOTSGs,Biological replicate1-Technical replicate 1
+ 17 more — browse all 57 samples with per-sample file links →
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