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Heritable fetal protection against MLL::ENL-driven leukemogenesis depends on MLL3

GSE291041 Mus musculus Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing 43 samples Submitted 2025/09/18 Platform GPL34328Platform GPL24247Platform GPL17021
SuperSeries — this record groups several sub-series.
Summary
This SuperSeries is composed of the SubSeries listed below.
This dataset
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Direct links to NCBI, no account and no request form: the whole study as GSE291041_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 43 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1231439 and SRA study SRP567819. Searching any of these in the dataset finder brings you back here.

Study design
8 conditions, mostly with about 4 replicates each
P0 WT LSK ×4 P0 MLL-ENL LSK (E10.5 ME) ×4 P28 WT LSK ×4 P28 MLL-ENL LSK (E10.5 ME) ×4 P28 MLL-ENL LSK (P0 ME) ×4 P28_Fetal_ME ×2 P28_WT ×2 E18_WT ×2 +14 more

Supports a between-group comparison across 26 samples.

8 replicated groups read from the first 40 of 43 sample titles; they account for 26 of them. Check it against the sample list below before relying on it.

Samples in this study

+ 3 more — browse all 43 samples with per-sample file links →

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