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Genetic variation in the activity of a TREM2-p53 signaling axis determines oxygeninduced lung injury

GSE274969 Mus musculus Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing 77 samples Submitted 2025/07/24 Platform GPL21103
Summary
To investigate the role of Trem2 in neonatal hyperoxia induced lung injury, we exposed mice to 75% oxygen for 14 days. We then performed gene expression profiling in whole lung and bone marrow derived macrophages using RNA-seq. We studied gene regulation using ChIP-seq.
Published in
Genetic variation in the activity of a TREM2-p53 signaling axis determines oxygen-induced lung injury
Abe Y, Spann NJ, Tang W et al. · Nature immunology 2025 · PMID 40715658 · doi:10.1038/s41590-025-02217-4
This dataset
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Direct links to NCBI, no account and no request form: the whole study as GSE274969_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 77 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1148661 and SRA study SRP526712. Searching any of these in the dataset finder brings you back here.

Study design
14 conditions, mostly in duplicate
B6_Nx_Lung ×4 DBA_Nx_Lung ×4 DBA_Hprx_Lung ×4 T2KO_Nx_Lung ×4 T2KO_Hprx_Lung ×4 B6_Hprx_Lung ×3 B6_Nx_Lung_ChIP_Input ×3 B6_Nx_BMDM ×2 +6 more

Supports a between-group comparison across 40 samples.

14 replicated groups read from the first 40 of 77 sample titles; they account for 40 of them. Check it against the sample list below before relying on it.

Samples in this study

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