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T cell receptor signaling induces expression of lysine demethylase KDM6B to maintain Treg homeostasis

GSE291449 Mus musculus Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing 46 samples Submitted 2026/04/08 Platform GPL21103Platform GPL34328Platform GPL24247
SuperSeries — this record groups several sub-series.
Summary
This SuperSeries is composed of the SubSeries listed below.
Published in
T cell receptor signaling induces expression of lysine demethylase KDM6B to maintain Treg homeostasis
He M, Xu B, Bose PG et al. · The Journal of clinical investigation 2026 · PMID 42024441 · doi:10.1172/JCI196022
This dataset
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Direct links to NCBI, no account and no request form: the whole study as GSE291449_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 46 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1233775 and SRA study SRP568964. Searching any of these in the dataset finder brings you back here.

Study design
13 conditions, mostly in triplicate
WT_Lung_Naive ×3 WT_Lung_Flu ×3 Kdm6b_Lung_Naive ×3 Kdm6b_Lung_Flu ×3 H3K27me3-Kdm6b_Lung_Flu ×3 H3K27me3-Kdm6b_Lung_PBS ×3 H3K27me3-WT_Lung_Flu ×3 H3K27me3-WT_Lung_PBS ×3 +11 more

Supports a between-group comparison across 34 samples.

13 replicated groups read from the first 40 of 46 sample titles; they account for 34 of them. Check it against the sample list below before relying on it.

Samples in this study

+ 6 more — browse all 46 samples with per-sample file links →

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