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DNMT3b mediates TGFβ-Smad2/3 action to maintain Epiblast homeostasis upon Smad4 Loss

GSE240787 Mus musculus Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing 34 samples Submitted 2024/10/21 Platform GPL24247Platform GPL34290Platform GPL17021
SuperSeries — this record groups several sub-series.
Summary
This SuperSeries is composed of the SubSeries listed below.
Published in
A stepwise mode of TGFβ-SMAD signaling and DNA methylation regulates naïve-to-primed pluripotency and differentiation
Zhao B, Yu X, Shi J et al. · Nature communications 2024 · PMID 39578449 · doi:10.1038/s41467-024-54433-5
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Direct links to NCBI, no account and no request form: the whole study as GSE240787_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 34 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1005240 and SRA study SRP454916. Searching any of these in the dataset finder brings you back here.

Study design
26 conditions, each sampled once — no replicated groups
WT_D0 ×2 WT_D4 ×2 S2/3DKO_D0 ×2 S2/3DKO_D4 ×2 S4KO_D0 ×2 S4KO_D4 ×2 E14_EB_Dnmt3b CUT&Tag ×2 S4KO_EB_Dnmt3b CUT&Tag ×2

Read from 34 sample titles: 26 distinct titles with little repetition. Check it against the sample list below before relying on it.

Samples in this study
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