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Role of progesterone receptor in inguinal hernia formation via skeletal muscle fibrosis [Hernia_Multiomics]

GSE288662 Mus musculus Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing 20 samples Submitted 2025/06/03 Platform GPL24247
Summary
Inguinal hernia development has been linked to fibrosis and atrophy of the lower abdominal muscle (LAM). We have shown that exogenous adminstration of estradiol (E2) and progesterone (P4) in mice can induce LAM fibrosis, muscle atrophy, and hernia development in mice, and that concurrent inhibition of progesterone receptor signaling using the drug RU486 can prevent this process. Utilizing a combination of single-nuclear transcriptomics and epigenomics, we analyzed the effects of E2 and P4 on the different cell types in the LAM to determine how these compounds contribute to hernia development.
Published in
Role of progesterone action in inguinal hernia formation via skeletal muscle fibrosis and atrophy
You T, Zandigohar M, Potluri T et al. · JCI insight 2025 · PMID 40504614 · doi:10.1172/jci.insight.193208
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Direct links to NCBI, no account and no request form: the whole study as GSE288662_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 20 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1218814 and SRA study SRP561369. Searching any of these in the dataset finder brings you back here.

Study design
20 conditions, each sampled once — no replicated groups

Read from 20 sample titles: 20 distinct titles with little repetition. Check it against the sample list below before relying on it.

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