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Cell of origin epigenetic priming determines susceptibility to Tet2 oncogenic mutation

GSE247970 Mus musculus Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing 76 samples Submitted 2024/03/14 Platform GPL21626Platform GPL24247
SuperSeries — this record groups several sub-series.
Summary
This SuperSeries is composed of the SubSeries listed below.
Published in
Cell of origin epigenetic priming determines susceptibility to Tet2 mutation
Schiroli G, Kartha V, Duarte FM et al. · Nature communications 2024 · PMID 38773071 · doi:10.1038/s41467-024-48508-6
This dataset
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Direct links to NCBI, no account and no request form: the whole study as GSE247970_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 76 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1041319 and SRA study SRP427252. Searching any of these in the dataset finder brings you back here.

Study design
6 conditions, mostly with about 5 replicates each
GMP_Tet2 ×5 Lin_neg_CD11b_Tet2 ×5 GMP_Control ×3 Lin_neg_CD11b_Control ×3 GMP_Tet2_Sox4OE ×2 Lin_neg_CD11b_Tet2_Sox4OE ×2 1_SCF_Control ×1 1_SCF_Tet ×1 +18 more

Supports a between-group comparison across 20 samples.

6 replicated groups read from the first 40 of 76 sample titles; they account for 20 of them. Check it against the sample list below before relying on it.

Samples in this study

+ 36 more — browse all 76 samples with per-sample file links →

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