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Extracellular matrix reprogramming by the YAP/TAZ/TGF-ß2 axis drives immune exclusion in cholangiocarcinoma models

GSE301501 Mus musculus Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing 45 samples Submitted 2026/06/15 Platform GPL19057Platform GPL24247
SuperSeries — this record groups several sub-series.
Summary
This SuperSeries is composed of the SubSeries listed below.
This dataset
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Direct links to NCBI, no account and no request form: the whole study as GSE301501_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 45 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1285336 and SRA study SRP597423. Searching any of these in the dataset finder brings you back here.

Study design
9 conditions, mostly with about 4 replicates each
shRen ×5 [ATAC-Seq] shRen ×5 shRen_YAP ×4 shRen_Tead1 ×4 shRen_H3K27Ac ×4 shRen_H3K4me1 ×4 shRen_IgG ×4 shYT#1 ×2 +7 more

Supports a between-group comparison across 34 samples.

9 replicated groups read from the first 40 of 45 sample titles; they account for 34 of them. Check it against the sample list below before relying on it.

Samples in this study

+ 5 more — browse all 45 samples with per-sample file links →

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