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Engineered bacteria as exogenous organelle mimics restore PTEN and p53 tumor suppressor functions for cancer therapy

GSE322551 Mus musculus Expression profiling by high throughput sequencing 30 samples Submitted 2026/07/24 Platform GPL24247
Summary
This work establishes a novel paradigm for using engineered intracellular bacteria asexogenous organelle-like systems to restore tumor suppressor functions and offers a promising strategy for cancer therapy
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Direct links to NCBI, no account and no request form: the whole study as GSE322551_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 30 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1430413 and SRA study SRP680214. Searching any of these in the dataset finder brings you back here.

Study design
6 conditions, mostly with about 5 replicates each
A ×5 B ×5 C ×5 D ×5 E ×5 F ×5

Supports a between-group comparison across 30 samples.

6 replicated groups read from 30 sample titles; they account for 30 of them. Check it against the sample list below before relying on it.

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