GEO series

Inflammatory Neuropathy in Mouse and Primate Models of Colorectal Cancer

GSE338763 Mus musculus Expression profiling by high throughput sequencing 24 samples Submitted 2026/07/17 Platform GPL24247

Summary

Colorectal cancer survivors are at increased risk of developing neurological issues, particularly peripheral neuropathy and chronic pain. Although pre-existing neuropathy is a risk factor for chronic pain, tumor-induced neuropathy has not been firmly established in pre-clinical models. Consistent with clinical observations, we show that mice with colorectal cancer develop peripheral neuropathy, which was associated with subtle locomotor deficits, without overt hypersensitivity. We detected widespread differences in pro-inflammatory cytokines and lipid metabolites in peripheral nerves from tumor-bearing mice. Macrophage accumulation, myelin decompaction and ryanodine receptor oxidation were associated with dysfunctional calcium homeostasis and reduced spike amplitude in sensory neurons. Similar alterations in plasma inflammatory mediators and lipid metabolites were associated with neuropathy and macrophage accumulation in peripheral nerves of rhesus macaques with colorectal cancer. These findings suggest colorectal cancer is causally linked to a subacute form of chronic inflammatory demyelinating polyneuropathy across species, which may represent an under-reported, yet important risk factor for neurological dysfunction in colorectal cancer survivors.

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Direct links to NCBI, no account and no request form: the whole study as GSE338763_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 24 samples. Raw sequencing reads are also available from ENA.

Whole study · RAW.tar ↓ Series matrix ↓ All supplementary files ↗ Raw reads on ENA ↗

Also filed as BioProject PRJNA1495836 and SRA study SRP718310. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗

Study design

8 conditions, mostly in triplicate

BMDM Vehicle ×3 BMDM MC38 ×3 SC Vehicle ×3 SC MC38 ×3 BMDM Vehicle intact ×3 BMDM Vehicle Deple ×3 MC38 Vehicle intact ×3 MC38 Vehicle Deple ×3

Supports a between-group comparison across 24 samples.

8 replicated groups read from 24 sample titles; they account for 24 of them. Check it against the sample list below before relying on it.

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