GEO series
Gene expression profile at single cell level of cells isolated from the bone fracture gap and un-injured bone marrow in mouse osteotomy models
GSE230260
Mus musculus
Expression profiling by high throughput sequencing
15 samples
Submitted 2025/02/14
Platform GPL24247
Summary
We investigated the cell composition in the bone fracture (osteotomy) gap under two different ambulatory loading conditions (stiif vs. compliant - external fixator). In addition, we applied an receptor inhibitor or respective isotype control to understand the role of a specific progenitor subpopulation during the onset of bone fracture repair. Un-injured bone marrow was used as control. Some samples were combined prior to library prep as indicated in the sample titles
Published in
Lang A, Collins JM, Nijsure MP et al.
· bioRxiv : the preprint server for biology 2025
· PMID 39829797
· doi:10.1101/2025.01.10.632440
This dataset
Download
Direct links to NCBI, no account and no request form: the whole study as GSE230260_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 15 samples. Raw sequencing reads are also available from ENA.
Also filed as BioProject PRJNA958141 and SRA study SRP433736. Searching any of these in the dataset finder brings you back here.
Study design
15 conditions, each sampled once — no replicated groups
Read from 15 sample titles: 15 distinct titles with little repetition. Check it against the sample list below before relying on it.
Samples in this study
0 selected
- GSM7210916 S1 Contralateral bone marrow, sample 1, External fixation rigid, Isotype control, scRNAseq
- GSM7210917 S1 Fracture gap, sample 1, External fixation rigid, Isotype control, scRNAseq
- GSM7210918 S2 Fracture gap, sample 2, External fixation rigid, Cd71 antibody, scRNAseq
- GSM7210919 S5 Contralateral bone marrow, sample 5, External fixation rigid, Isotype control, scRNAseq
- GSM7210920 S5 Fracture gap, sample 5, External fixation rigid, Isotype control, scRNAseq
- GSM7210921 S6 Fracture gap, sample 6, External fixation rigid, Cd71 antibody, scRNAseq
- GSM7210922 S7 and S8, Fracture gap, sample 7/8, External fixation compliant, isotype control, scRNAseq
- GSM7210923 S9 and S10, Fracture gap, sample 9/10, External fixation compliant, Cd71 antibody, scRNAseq
- GSM7210924 S11 Contralateral bone marrow, sample 11, External fixation rigid, Isotype control, scRNAseq
- GSM7210925 S11 Fracture gap, sample 11, External fixation rigid, Isotype control, scRNAseq
- GSM7210926 S12 Fracture gap, sample 12, External fixation rigid, Cd71 antibody, scRNAseq
- GSM7210927 S13 and S14, Fracture gap, sample 13/14, External fixation compliant, isotype control, scRNAseq
- GSM7210928 S15 and S16, Fracture gap, sample 15/16, External fixation compliant, isotype control, scRNAseq
- GSM7210929 S17 and S18, Fracture gap, sample 17/18, External fixation compliant, isotype control, scRNAseq
- GSM7210930 S19 and S20, Fracture gap, sample 19/20, External fixation compliant, isotype control, scRNAseq
Similar datasets
- GSE297921 Single-cell sequencing of CD45+ cells isolated from nasal mucosa of mice 18 samples
- GSE293709 Transcriptome analysis in the prefrontal cortex of different ASD mouse models treated with drug 1565 samples
- GSE278990 Single-cell screens identify ADAM12 as a fibroblast checkpoint impeding anti-tumor immunity 73 samples
- GSE263383 Unbiased niche labeling maps immune-excluded niche in bone metastasis 33 samples
- GSE300288 Single-cell and spatial transcriptomics analysis of tobacco-associated lung adenocarcinoma development, and in response to targeting inflammation alone or in combination with immune checkpoint blockade in precancerous phase [scRNA-seq] 31 samples
- GSE327176 Single-cell transcriptomic profiling unveils tumor-mediated reprogramming of neutrophils and their unique vulnerability that inhibits metastasis 25 samples
- GSE338763 Inflammatory Neuropathy in Mouse and Primate Models of Colorectal Cancer 24 samples
- GSE319238 Single-cell transcriptomic analysis of microglia and brain cells after ischemic stroke 12 samples
Share this dataset
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.