Rejuvenating endogenous antitumor immunity via a chimeric receptor-engineered oncolytic virus targeting tumor-associated macrophages

Direct links to NCBI, no account and no request form: the whole study as GSE272424_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1136852 and SRA study SRP520514. Searching any of these in the dataset finder brings you back here.

Read from 6 sample titles: 6 distinct titles with little repetition. Check it against the sample list below before relying on it.

• GSM8401835 Vehicle, replicate 1, scRNAseq
• GSM8401836 Vehicle, replicate 2, scRNAseq
• GSM8401837 d0-GFP, replicate 1, scRNAseq
• GSM8401838 d0-GFP, replicate 2, scRNAseq
• GSM8401839 dgD-aPDL1, replicate 1, scRNAseq
• GSM8401840 dgD-aPDL1, replicate 2, scRNAseq

• GSE319035 P21+TREM2+-Senescent Macrophages Fuel Inflammaging and Metabolic Dysfunction-Associated Steatotic Liver Disease [NAFLD_time_course] 77 samples
• GSE278990 Single-cell screens identify ADAM12 as a fibroblast checkpoint impeding anti-tumor immunity 73 samples
• GSE300288 Single-cell and spatial transcriptomics analysis of tobacco-associated lung adenocarcinoma development, and in response to targeting inflammation alone or in combination with immune checkpoint blockade in precancerous phase [scRNA-seq] 31 samples
• GSE322551 Engineered bacteria as exogenous organelle mimics restore PTEN and p53 tumor suppressor functions for cancer therapy 30 samples
• GSE337190 CAR-NKT cells induce low cytokine release syndrome by targeting hyperinflammatory macrophages with mitigation from GM-SCF inhibition. 24 samples
• GSE269187 ZEB2 is a Master Switch Controlling the Tumor-Associated Macrophage Program [in vitro] 17 samples
• GSE281001 The C3-C3aR axis modulates trained immunity in alveolar macrophages 8 samples
• GSE306262 Astrocyte glucocorticoid receptor signaling restricts neuronal plasticity [RNA-seq] 40 samples

Search all mouse RNA-seq datasets in GEO →