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High-resolution and noninvasive profiling of the tumor microenvironment with spatial ecotypes

GSE320042 Homo sapiens Expression profiling by high throughput sequencing; Other 38 samples Submitted 2026/05/06 Platform GPL34281Platform GPL24676
SuperSeries — this record groups several sub-series.
Summary
This SuperSeries is composed of the SubSeries listed below.
Published in
Non-invasive profiling of the tumour microenvironment with spatial ecotypes
Zhang W, Brown EL, Usmani A et al. · Nature 2026 · PMID 42092150 · doi:10.1038/s41586-026-10452-4
This dataset
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Direct links to NCBI, no account and no request form: the whole study as GSE320042_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 38 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1426040. Searching any of these in the dataset finder brings you back here.

Study design
8 conditions, mostly with about 4 replicates each
Melanoma, WU ×9 CRC; Intact tissue; WU ×4 CRC; Dissociated tissue; WU ×4 CRC, WU ×4 Melanoma; Intact tissue; WU ×3 Melanoma; Dissociated tissue; WU ×3 Melanoma, WU1384, ×2 Melanoma, WU2130, ×2 +7 more

Supports a between-group comparison across 31 samples.

8 replicated groups read from 38 sample titles; they account for 31 of them. Check it against the sample list below before relying on it.

Samples in this study
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