GEO series
Spatial and single cell transcriptomics reveals cellular crosstalk changes in ileal Crohn’s disease during inflammation
GSE228360
Homo sapiens
Expression profiling by high throughput sequencing; Other
24 samples
Submitted 2025/04/01
Platform GPL24676
Summary
Crohn’s disease is a lifelong disease with no cure that requires a better characterization of the cellular milieu and behavior that drives disease progression if more targeted therapies are to be developed. Our work with spatial and single cell transcriptomics adds new knowledge and gives spatial context to the cellular behavior and communication occurring within the intestinal mucosa during Crohn’s disease and how it is affected by inflammation.
Published in
Kolachala VL, Maddipatla SC, Murthy S et al.
· JCI insight 2025
· PMID 40059828
· doi:10.1172/jci.insight.171783
This dataset
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Direct links to NCBI, no account and no request form: the whole study as GSE228360_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 24 samples. Raw sequencing reads are also available from ENA.
Also filed as BioProject PRJNA949559 and SRA study SRP429734. Searching any of these in the dataset finder brings you back here.
Study design
24 conditions, each sampled once — no replicated groups
Read from 24 sample titles: 24 distinct titles with little repetition. Check it against the sample list below before relying on it.
Samples in this study
0 selected
- GSM7119390 Ileal mucosal cells, Crohns Disease [Sc1]
- GSM7119391 Ileal mucosal cells, Crohns Disease [Sc2]
- GSM7119392 Ileal mucosal cells, Crohns Disease [Sc3]
- GSM7119393 Ileal mucosal cells, Crohns Disease [Sc4]
- GSM7119394 Ileal mucosal cells, Crohns Disease [Sc5]
- GSM7119395 Ileal mucosal cells, Crohns Disease [Sc6]
- GSM7119396 Ileal mucosal cells, Crohns Disease [Sc7]
- GSM7119397 Ileal mucosal cells, Crohns Disease [Sc8]
- GSM7119398 Ileal mucosal cells, Crohns Disease [Sc9]
- GSM7119399 Ileal mucosal cells, Crohns Disease [Sc10]
- GSM7119400 Ileal mucosal cells, Crohns Disease [Sc11]
- GSM7119401 Ileal mucosal cells, Crohns Disease [Sc12]
- GSM7119402 Ileal Surgical tissue, Crohns Disease [ST1]
- GSM7119403 Ileal Surgical tissue, Crohns Disease [ST2]
- GSM7119404 Ileal Surgical tissue, Crohns Disease [ST3]
- GSM7119405 Ileal Surgical tissue, Crohns Disease [ST4]
- GSM7119406 Ileal Surgical tissue, Crohns Disease [ST5]
- GSM7119407 Ileal Surgical tissue, Crohns Disease [ST6]
- GSM7119408 Ileal Surgical tissue, Crohns Disease [ST7]
- GSM7119409 Ileal Surgical tissue, Crohns Disease [ST8]
- GSM7119410 Ileal Surgical tissue, Crohns Disease [ST9]
- GSM7119411 Ileal Surgical tissue, Crohns Disease [ST10]
- GSM7119412 Ileal Surgical tissue, Crohns Disease [ST11]
- GSM7119413 Ileal Surgical tissue, Crohns Disease [ST12]
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