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Multi-scaled transcriptomics of chronically inflamed nasal epithelium reveals immune-epithelial dynamics and tissue remodeling in nasal polyp formation

GSE235715 Homo sapiens Expression profiling by high throughput sequencing; Other 60 samples Submitted 2025/10/06 Platform GPL20301Platform GPL21697
SuperSeries — this record groups several sub-series.
Summary
This SuperSeries is composed of the SubSeries listed below.
Published in
Multi-scaled transcriptomics of chronically inflamed nasal epithelium reveals immune-epithelial dynamics and tissue remodeling in nasal polyp formation
Liao G, Nakayama T, Zhu B et al. · Immunity 2025 · PMID 40945518 · doi:10.1016/j.immuni.2025.08.009
This dataset
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Direct links to NCBI, no account and no request form: the whole study as GSE235715_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 60 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA986939 and SRA study SRP445589. Searching any of these in the dataset finder brings you back here.

Study design
10 conditions, mostly in duplicate
CRSwNP_4, CD45+ ROI ×2 CRSwNP_5, CD45+ ROI ×2 CRSwNP_6, CD45+ ROI ×2 CRSwNP_7, CD45+ ROI ×2 CRSwNP_8, CD45+ ROI ×2 CRSwNP_9, CD45+ ROI ×2 CTRL_6, CD45+ ROI ×2 CTRL_7, CD45+ ROI ×2 +22 more

Supports a between-group comparison across 20 samples.

10 replicated groups read from the first 40 of 60 sample titles; they account for 20 of them. Check it against the sample list below before relying on it.

Samples in this study

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