GEO series
Immune-microbiome coordination defines interferon setpoints in healthy humans [CITE-seq and WMS]
GSE314416
Homo sapiens
Expression profiling by high throughput sequencing; Other
108 samples
Submitted 2026/03/09
Platform GPL24676Platform GPL34281
Summary
Human immune systems are highly variable, with most variation attributable to non-genetic sources. The gut microbiome crucially shapes the immune system; however, its relationship with the baseline immune states of healthy humans remains incompletely understood. Therefore, we performed multi-omic profiling of 110 healthy participants through the ImmunoMicrobiome study. A factor-based integrative approach identified coordinated variation, revealing that the interferon response was amongst the most variable immune features in healthy participants. Microbiome composition, pathways, and stool metabolites varied concomitantly with interferon response pathways. Longitudinal data spanning more than a year indicated the significant stability of these parameters within individuals over time. Our study provides extensive data to examine the relationship between the immune states and microbiomes of healthy individuals at steady state, which paves the way for delineating inter-individual differences relevant for disease susceptibility and responses to therapy.
Published in
Babdor J, Patel RK, Davidson B et al.
· Cell 2026
· PMID 41806833
· doi:10.1016/j.cell.2026.02.003
This dataset
Download
Direct links to NCBI, no account and no request form: the whole study as GSE314416_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 108 samples. Raw sequencing reads are also available from ENA.
Also filed as BioProject PRJNA1390888 and SRA study SRP656586. Searching any of these in the dataset finder brings you back here.
Study design
40 conditions, each sampled once — no replicated groups
Read from the first 40 of 108 sample titles: 40 distinct titles with little repetition. Check it against the sample list below before relying on it.
Samples in this study
0 selected
- GSM9396035 pool-1, well-1, GEX
- GSM9396036 pool-1, well-1, ADT
- GSM9396037 pool-1, well-2, GEX
- GSM9396038 pool-1, well-2, ADT
- GSM9396039 pool-1, well-3, GEX
- GSM9396040 pool-1, well-3, ADT
- GSM9396041 pool-1, well-4, GEX
- GSM9396042 pool-1, well-4, ADT
- GSM9396043 pool-10, well-1, GEX
- GSM9396044 pool-10, well-1, ADT
- GSM9396045 pool-10, well-2, GEX
- GSM9396046 pool-10, well-2, ADT
- GSM9396047 pool-10, well-3, GEX
- GSM9396048 pool-10, well-3, ADT
- GSM9396049 pool-10, well-4, GEX
- GSM9396050 pool-10, well-4, ADT
- GSM9396051 pool-11, well-1, GEX
- GSM9396052 pool-11, well-1, ADT
- GSM9396053 pool-11, well-2, GEX
- GSM9396054 pool-11, well-2, ADT
- GSM9396055 pool-11, well-3, GEX
- GSM9396056 pool-11, well-3, ADT
- GSM9396057 pool-11, well-4, GEX
- GSM9396058 pool-11, well-4, ADT
- GSM9396059 pool-12, well-1, GEX
- GSM9396060 pool-12, well-1, ADT
- GSM9396061 pool-12, well-2, GEX
- GSM9396062 pool-12, well-2, ADT
- GSM9396063 pool-12, well-3, GEX
- GSM9396064 pool-12, well-3, ADT
- GSM9396065 pool-12, well-4, GEX
- GSM9396066 pool-12, well-4, ADT
- GSM9396067 pool-13, well-1, GEX
- GSM9396068 pool-13, well-1, ADT
- GSM9396069 pool-13, well-2, GEX
- GSM9396070 pool-13, well-2, ADT
- GSM9396071 pool-13, well-3, GEX
- GSM9396072 pool-13, well-3, ADT
- GSM9396073 pool-13, well-4, GEX
- GSM9396074 pool-13, well-4, ADT
+ 68 more — browse all 108 samples with per-sample file links →
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