GEO series
The critical role of the host endogenous immune compartment after intracerebroventricular CAR T cell therapy in recurrent GBM
GSE296419
Homo sapiens
Expression profiling by high throughput sequencing; Other
143 samples
Submitted 2026/06/30
Platform GPL18573Platform GPL24676Platform GPL34281
Summary
Glioblastoma (GBM) is the most common primary malignant brain tumor in adults, with a median survival of under 15 months and no effective treatment after recurrence. A recent phase I trial of intracerebroventricular (ICV) bivalent CAR T cells in recurrent GBM showed promising responses, including tumor reduction and prolonged survival. However, relapse remains common. We performed in-depth profiling of longitudinal CSF and tumor samples from responders and non-responders to characterize immune dynamics following infusion. Our study reveals that while CAR T cells activate post-infusion across all patients, outcomes were defined by divergent remodeling of the endogenous immune landscape. Cytotoxic NK cell expansion characterized responders, whereas regulatory T cell expansion and abundant baseline immunosuppressive myeloid cells characterized non-responders. These findings indicate that host immune cells play a critical role in ICV CAR T cell therapy for GBM, suggesting that combinatorial strategies modulating the endogenous immune compartment could improve next-generation treatments.
This dataset
Download
Direct links to NCBI, no account and no request form: the whole study as GSE296419_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 143 samples. Raw sequencing reads are also available from ENA.
Also filed as BioProject PRJNA1258285. Searching any of these in the dataset finder brings you back here.
Study design
38 conditions, each sampled once — no replicated groups
CSF_P5D0_GEX ×2
CSF_P5D0_VDJ ×2
Read from the first 40 of 143 sample titles: 38 distinct titles with little repetition. Check it against the sample list below before relying on it.
Samples in this study
0 selected
- GSM8970097 CSF_P1D0_GEX
- GSM8970098 CSF_P1D7_GEX
- GSM8970099 CSF_P1D21_GEX
- GSM8970100 CSF_P1D0_VDJ
- GSM8970101 CSF_P1D7_VDJ
- GSM8970102 CSF_P1D21_VDJ
- GSM8970103 CSF_P2D0_GEX
- GSM8970104 CSF_P2D7_GEX
- GSM8970105 CSF_P2D21_GEX
- GSM8970106 CSF_P2D0_VDJ
- GSM8970107 CSF_P2D7_VDJ
- GSM8970108 CSF_P2D21_VDJ
- GSM8970109 CSF_P3D0_GEX
- GSM8970110 CSF_P3D7_GEX
- GSM8970111 CSF_P3D21_GEX
- GSM8970112 CSF_P3D0_VDJ
- GSM8970113 CSF_P3D7_VDJ
- GSM8970114 CSF_P3D21_VDJ
- GSM8970115 CSF_P4D0_GEX
- GSM8970116 CSF_P4D7_GEX
- GSM8970117 CSF_P4D21_GEX
- GSM8970118 CSF_P4D0_VDJ
- GSM8970119 CSF_P4D7_VDJ
- GSM8970120 CSF_P4D21_VDJ
- GSM8970121 CSF_P5D0_GEX_run1
- GSM8970122 CSF_P5D0_GEX_run2
- GSM8970123 CSF_P5D7_GEX
- GSM8970124 CSF_P5D21_GEX
- GSM8970125 CSF_P5D0_VDJ_run1
- GSM8970126 CSF_P5D0_VDJ_run2
- GSM8970127 CSF_P5D7_VDJ
- GSM8970128 CSF_P5D21_VDJ
- GSM8970129 CSF_P6D0_GEX
- GSM8970130 CSF_P6D7_GEX
- GSM8970131 CSF_P6D21_GEX
- GSM8970132 CSF_P6D0_VDJ
- GSM8970133 CSF_P6D7_VDJ
- GSM8970134 CSF_P6D21_VDJ
- GSM8970135 CSF_P7D0_GEX
- GSM8970136 CSF_P7D7_GEX
+ 103 more — browse all 143 samples with per-sample file links →
Similar datasets
- GSE229733 Corticosteroid resistance is predetermined by early immune response dynamics at acute Graft-versus-Host disease onset 122 samples
- GSE338460 Immune hallmarks of recurrent immune checkpoint inhibitor-mediated inflammatory arthritis 25 samples
- GSE246342 CD4+ CAR-T cell exhaustion associated with early relapse of multiple myeloma after BCMA CAR-T cell therapy I 18 samples
- GSE189184 Divergent spatial microdomains drive inflammation and repair in Ulcerative and Immune Checkpoint Therapy Colitis - Spatial Transcriptomics 16 samples
- GSE269379 The CXCL16/CXCR6 axis is linked to immune effector cell-associated neurotoxicity in chimeric antigen receptor (CAR) T cell therapy 10 samples
- GSE272993 Combination anti-PD-1 and anti-CTLA-4 therapy generates waves of clonal responses that include progenitor-exhausted CD8 T cells [dataset 1] 360 samples
- GSE270387 Single cell profiling of peripheral blood mononuclear cells in diverse men with prostate cancer reveals lethal disease-associated immune signatures 165 samples
- GSE252959 Recruitment of plasma cells from follicular and extrafollicular immune reactions to the bone marrow I 152 samples
Share this dataset
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.