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BMAL1 and YAP cooperate to hijack enhancers and promote inflammation in the aged epidermis

GSE294389 Mus musculus Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing 131 samples Submitted 2026/06/29 Platform GPL30172Platform GPL17021
SuperSeries — this record groups several sub-series.
Summary
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This dataset
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Direct links to NCBI, no account and no request form: the whole study as GSE294389_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 131 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1249360 and SRA study SRP577254. Searching any of these in the dataset finder brings you back here.

Study design
5 conditions, mostly with about 4 replicates each
Young_H3K4me3_ChIP ×4 Old_H3K4me3_ChIP ×4 Young_H3K4me3_input ×4 Old_H3K4me3_input ×4 O0 ×4 Old_H3K27ac_ChIP ×1 Young_H3K27ac_ChIP ×1 Old_H3K4me1_ChIP ×1 +17 more

Supports a between-group comparison across 20 samples.

5 replicated groups read from the first 40 of 131 sample titles; they account for 20 of them. Check it against the sample list below before relying on it.

Samples in this study

+ 91 more — browse all 131 samples with per-sample file links →

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