← BioTransfer GEO Dataset Finder
GEO series

Childhood cancer mutagenesis caused by a domesticated DNA transposase

GSE249785 Mus musculus Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing 12 samples Submitted 2024/03/27 Platform GPL24247
Summary
Induction of somatic oncogenic mutations by the domesticated DNA transposase PGBD5 in cerebellar progenitor cells promotes medulloblastoma development.
Published in
Childhood cancer mutagenesis caused by transposase-derived PGBD5
Yamada M, Keller RR, Gutierrez RL et al. · Science advances 2024 · PMID 38517960 · doi:10.1126/sciadv.adn4649
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE249785_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 12 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1050329 and SRA study SRP476778. Searching any of these in the dataset finder brings you back here.

Study design
3 × Medulloblastoma, Ptf1a-Cre/+; Ptch1fl/fl; Pgbd5-/-, RNA, vs 3 × Medulloblastoma, Ptf1a-Cre/+; Ptch1fl/fl; Pgbd5+/+, RNA, vs 3 × Medulloblastoma, Ptf1a-Cre/+; Ptch1fl/fl; Pgbd5-/-, ATAC, vs 3 × Medulloblastoma, Ptf1a-Cre/+; Ptch1fl/fl; Pgbd5+/+, ATAC,

Supports a between-group comparison across 12 samples.

4 replicated groups read from 12 sample titles; they account for 12 of them. Check it against the sample list below before relying on it.

Samples in this study
Similar datasets

Search all mouse RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.