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Oxidative Stress Converts Benign Lesions to Cancer via a Self-Amplifying NRF2-EZH2 Loop

GSE214191 Mus musculus Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing 63 samples Submitted 2025/02/20 Platform GPL21103Platform GPL19057
SuperSeries — this record groups several sub-series.
Summary
This SuperSeries is composed of the SubSeries listed below.
Published in
Self-amplifying NRF2-EZH2 epigenetic loop converts KRAS-initiated progenitors to invasive pancreatic cancer
Antonucci L, Li N, Duran A et al. · Nature cancer 2025 · PMID 40588523 · doi:10.1038/s43018-025-01003-3
This dataset
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Direct links to NCBI, no account and no request form: the whole study as GSE214191_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 63 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA884323 and SRA study SRP399631. Searching any of these in the dataset finder brings you back here.

Study design
34 conditions, each sampled once — no replicated groups
Krascells_ATAC_Control_Clone ×2 Krascells_ATAC_EzhKO_Clone ×2 Krascells_ChIP_H3K27ac_Control_Clone ×2 Krascells_ChIP_H3K27ac_EzhKO_Clone ×2 Krascells_ChIP_H3K4me3_Control_Clone ×2 Krascells_ChIP_H3K4me3_EzhKO_Clone ×2

Read from the first 40 of 63 sample titles: 34 distinct titles with little repetition. Check it against the sample list below before relying on it.

Samples in this study

+ 23 more — browse all 63 samples with per-sample file links →

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