GEO series
ATAC-seq profiling of lineage-traced exhausted and memory-like CD8+ T cell subsets during tumor progression
GSE337898
Mus musculus
Genome binding/occupancy profiling by high throughput sequencing
24 samples
Submitted 2026/07/24
Platform GPL24247
Summary
To investigate the epigenetic landscape of tumor-reactive exhausted CD8+ T cells, ATAC-seq was performed on fluorescence-activated cell sorted CD8+ T cell subsets isolated from Lag3^iCreERT2^ Rosa26^LSL-tdTomato^ mice bearing B16-F10 melanoma tumors. Chromatin accessibility profiles were generated for lineage-traced LAG3^+tdTomato^+, LAG3^-tdTomato^+, and corresponding control CD8+ T cell populations isolated from tumors and draining lymphoid tissues. These data were used to characterize chromatin accessibility changes associated with exhausted, progenitor-like, and memory-like CD8+ T cell states and to define epigenetic relationships among lineage-traced T cell populations.
This dataset
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Direct links to NCBI, no account and no request form: the whole study as GSE337898_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 24 samples. Raw sequencing reads are also available from ENA.
Also filed as BioProject PRJNA1491467 and SRA study SRP716101. Searching any of these in the dataset finder brings you back here.
Study design
24 conditions, each sampled once — no replicated groups
Read from 24 sample titles: 24 distinct titles with little repetition. Check it against the sample list below before relying on it.
Samples in this study
0 selected
- GSM9862442 DLN DN CD8+ T cells ATAC-seq (replicate 1)
- GSM9862443 DLN DN CD8+ T cells ATAC-seq (replicate 2)
- GSM9862444 DLN LAG3-tdTomato+ CD8+ T cells ATAC-seq
- GSM9862445 DLN tdTomato+ CD8+ T cells ATAC-seq (replicate 1)
- GSM9862446 DLN tdTomato+ CD8+ T cells ATAC-seq (replicate 2)
- GSM9862447 NDLN DN CD8+ T cells ATAC-seq (replicate 1)
- GSM9862448 NDLN DN CD8+ T cells ATAC-seq (replicate 2)
- GSM9862449 NDLN LAG3-tdTomato+ CD8+ T cells ATAC-seq
- GSM9862450 NDLN tdTomato+ CD8+ T cells ATAC-seq (replicate 1)
- GSM9862451 NDLN tdTomato+ CD8+ T cells ATAC-seq (replicate 2)
- GSM9862452 Tumor DN CD8+ T cells ATAC-seq (replicate 1)
- GSM9862453 Tumor DN CD8+ T cells ATAC-seq (replicate 2)
- GSM9862454 Tumor DN CD8+ T cells ATAC-seq (replicate 3)
- GSM9862455 Tumor DN CD8+ T cells ATAC-seq (replicate 4)
- GSM9862456 Tumor LAG3+tdTomato+ CD8+ T cells ATAC-seq (replicate 1)
- GSM9862457 Tumor LAG3+tdTomato+ CD8+ T cells ATAC-seq (replicate 2)
- GSM9862458 Tumor LAG3+tdTomato+ CD8+ T cells ATAC-seq (replicate 3)
- GSM9862459 Tumor LAG3+tdTomato+ CD8+ T cells ATAC-seq (replicate 4)
- GSM9862460 Tumor LAG3-tdTomato+ CD8+ T cells ATAC-seq (replicate 1)
- GSM9862461 Tumor LAG3-tdTomato+ CD8+ T cells ATAC-seq (replicate 2)
- GSM9862462 Tumor LAG3-tdTomato+ CD8+ T cells ATAC-seq (replicate 3)
- GSM9862463 Tumor tdTomato+ CD8+ T cells ATAC-seq (replicate 1)
- GSM9862464 Tumor tdTomato+ CD8+ T cells ATAC-seq (replicate 2)
- GSM9862465 Tumor tdTomato+ CD8+ T cells ATAC-seq (replicate 3)
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