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Oncolytic virus therapy mobilizes tumor-resident CD4+ bystander T cells to restore systemic anti-microbial immunity [ATAC-seq]

GSE302620 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 16 samples Submitted 2025/08/06 Platform GPL24247
Summary
ATAC-seq library was prepared using Hyperactive ATAC-seq Library Prep Kit for Illumina (Vazyme, TD711) to study SM CD4+ T cells in lung and spleen when undergoing OV-BYTE treatment. Here, we further demonstrate that OV-BYTE delivered dual defense against tumorigenesis and pathogen infections in pre-clinical models. This study gives a epigenetic profiles of SM CD4+ T cells in lung and spleen with administration of OV-BYTE treatment.
Published in
Oncolytic virotherapy mobilizes tumor-resident, granzyme B-producing bystander CD4(+) T cells to inhibit systemic microbial infection
Yue S, He J, Ye S et al. · Molecular therapy. Oncology 2026 · PMID 42058600 · doi:10.1016/j.omton.2026.201187
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Direct links to NCBI, no account and no request form: the whole study as GSE302620_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 16 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1291592 and SRA study SRP601062. Searching any of these in the dataset finder brings you back here.

Study design
8 conditions, mostly in duplicate
Ly108+CD39- SM cells, PBS group, tumor, ×2 Ly108+CD39- SM cells, NDV-WT group, tumor, ×2 Ly108+CD39- SM cells, NDV-GP group, tumor, ×2 Ly108-CD39+ SM cells, NDV-GP group, tumor, ×2 Ly108+CD39- SM cells, PBS group, spleen, ×2 Ly108+CD39- SM cells, NDV-WT group, spleen, ×2 Ly108+CD39- SM cells, NDV-GP group, spleen, ×2 Ly108-CD39+ SM cells, NDV-GP group, spleen, ×2

Supports a between-group comparison across 16 samples.

8 replicated groups read from 16 sample titles; they account for 16 of them. Check it against the sample list below before relying on it.

Samples in this study
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