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Maternal high-fat diet alters Tet-mediated epigenetic regulation during heart development [ATAC-Seq]

GSE271883 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 12 samples Submitted 2025/08/01 Platform GPL21103
Summary
Our study suggested a direct link between maternal high-fat diet exposure and TET-mediated epigenetic regulation during heart development. Furthermore, we also uncovered beneficial effects of maternal vitamin C intake to protect heart development under maternal obesity conditions
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Direct links to NCBI, no account and no request form: the whole study as GSE271883_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 12 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1133796 and SRA study SRP518933. Searching any of these in the dataset finder brings you back here.

Study design
3 × Normal Diet, No Vitamin C, vs 3 × Normal Diet, Vitamin C, vs 3 × High Fat Diet, No Vitamin C, vs 3 × High Fat Diet, Vitamin C,

Supports a between-group comparison across 12 samples.

4 replicated groups read from 12 sample titles; they account for 12 of them. Check it against the sample list below before relying on it.

Samples in this study
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