GEO series
Promoter mutagenesis and a massively parallel reporter screen of the MAPT locus identifies cis-regulatory elements and genetic variation effects
GSE325670
Homo sapiens
Expression profiling by high throughput sequencing; Other
140 samples
Submitted 2026/03/23
Platform GPL18573Platform GPL24676Platform GPL34284
SuperSeries — this record groups several sub-series.
Summary
This SuperSeries is composed of the SubSeries listed below.
Published in
Hauser RM, Limbo HL, Brazell JN et al.
· bioRxiv : the preprint server for biology 2026
· PMID 41959502
· doi:10.64898/2026.03.06.710116
This dataset
Download
Direct links to NCBI, no account and no request form: the whole study as GSE325670_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 140 samples. Raw sequencing reads are also available from ENA.
Also filed as BioProject PRJNA1441453. Searching any of these in the dataset finder brings you back here.
Study design
7 conditions, mostly with about 5 replicates each
Mixed Neuron Culture, CRISPRi AAV Safe Harbor, ×9
Mixed Neuron Culture, CRISPRi MAPT promoter, ×9
Mixed Neuron Culture, CRISPRi region r1, ×5
Mixed Neuron Culture, CRISPRi region r2, ×5
Mixed Neuron Culture, CRISPRi region r3, ×5
Mixed Neuron Culture, CRISPRi region r4, ×5
Mixed Neuron Culture, CRISPRi region r5, ×2
Supports a between-group comparison across 40 samples.
7 replicated groups read from the first 40 of 140 sample titles; they account for 40 of them. Check it against the sample list below before relying on it.
Samples in this study
0 selected
- GSM9575993 Mixed Neuron Culture, CRISPRi AAV Safe Harbor, replicate 1
- GSM9575994 Mixed Neuron Culture, CRISPRi AAV Safe Harbor, replicate 2
- GSM9575995 Mixed Neuron Culture, CRISPRi AAV Safe Harbor, replicate 3
- GSM9575996 Mixed Neuron Culture, CRISPRi AAV Safe Harbor, replicate 4
- GSM9575997 Mixed Neuron Culture, CRISPRi AAV Safe Harbor, replicate 5
- GSM9575998 Mixed Neuron Culture, CRISPRi AAV Safe Harbor, replicate 6
- GSM9575999 Mixed Neuron Culture, CRISPRi AAV Safe Harbor, replicate 7
- GSM9576000 Mixed Neuron Culture, CRISPRi AAV Safe Harbor, replicate 8
- GSM9576001 Mixed Neuron Culture, CRISPRi AAV Safe Harbor, replicate 9
- GSM9576002 Mixed Neuron Culture, CRISPRi MAPT promoter, replicate 1
- GSM9576003 Mixed Neuron Culture, CRISPRi MAPT promoter, replicate 2
- GSM9576004 Mixed Neuron Culture, CRISPRi MAPT promoter, replicate 3
- GSM9576005 Mixed Neuron Culture, CRISPRi MAPT promoter, replicate 4
- GSM9576006 Mixed Neuron Culture, CRISPRi MAPT promoter, replicate 5
- GSM9576007 Mixed Neuron Culture, CRISPRi MAPT promoter, replicate 6
- GSM9576008 Mixed Neuron Culture, CRISPRi MAPT promoter, replicate 7
- GSM9576009 Mixed Neuron Culture, CRISPRi MAPT promoter, replicate 8
- GSM9576010 Mixed Neuron Culture, CRISPRi MAPT promoter, replicate 9
- GSM9576011 Mixed Neuron Culture, CRISPRi region r1, replicate 1
- GSM9576012 Mixed Neuron Culture, CRISPRi region r1, replicate 2
- GSM9576013 Mixed Neuron Culture, CRISPRi region r1, replicate 3
- GSM9576014 Mixed Neuron Culture, CRISPRi region r1, replicate 4
- GSM9576015 Mixed Neuron Culture, CRISPRi region r1, replicate 5
- GSM9576016 Mixed Neuron Culture, CRISPRi region r2, replicate 1
- GSM9576017 Mixed Neuron Culture, CRISPRi region r2, replicate 2
- GSM9576018 Mixed Neuron Culture, CRISPRi region r2, replicate 3
- GSM9576019 Mixed Neuron Culture, CRISPRi region r2, replicate 4
- GSM9576020 Mixed Neuron Culture, CRISPRi region r2, replicate 5
- GSM9576021 Mixed Neuron Culture, CRISPRi region r3, replicate 1
- GSM9576022 Mixed Neuron Culture, CRISPRi region r3, replicate 2
- GSM9576023 Mixed Neuron Culture, CRISPRi region r3, replicate 3
- GSM9576024 Mixed Neuron Culture, CRISPRi region r3, replicate 4
- GSM9576025 Mixed Neuron Culture, CRISPRi region r3, replicate 5
- GSM9576026 Mixed Neuron Culture, CRISPRi region r4, replicate 1
- GSM9576027 Mixed Neuron Culture, CRISPRi region r4, replicate 2
- GSM9576028 Mixed Neuron Culture, CRISPRi region r4, replicate 3
- GSM9576029 Mixed Neuron Culture, CRISPRi region r4, replicate 4
- GSM9576030 Mixed Neuron Culture, CRISPRi region r4, replicate 5
- GSM9576031 Mixed Neuron Culture, CRISPRi region r5, replicate 1
- GSM9576032 Mixed Neuron Culture, CRISPRi region r5, replicate 2
+ 100 more — browse all 140 samples with per-sample file links →
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