GEO series
Immunosuppressive monocytes are enriched in hepatocellular carcinoma patients with liver dysfunction in a phase II trial of combination sorafenib and nivolumab
GSE318420
Homo sapiens
Expression profiling by high throughput sequencing; Other
210 samples
Submitted 2026/02/04
Platform GPL24676
SuperSeries — this record groups several sub-series.
Summary
This SuperSeries is composed of the SubSeries listed below.
Published in
Keenan BP, Fan Z, Le BK et al.
· JHEP reports : innovation in hepatology 2026
· PMID 41831609
· doi:10.1016/j.jhepr.2026.101817
This dataset
Download
Direct links to NCBI, no account and no request form: the whole study as GSE318420_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 210 samples. Raw sequencing reads are also available from ENA.
Also filed as BioProject PRJNA1418700 and SRA study SRP654876. Searching any of these in the dataset finder brings you back here.
Study design
34 conditions, each sampled once — no replicated groups
PBMC healthy donor scRNA-seq replicate 1 ×4
HCC PBMC patient A-07 timepoint C2D1 scRNA-seq ×2
HCC PBMC patient A-04 timepoint C2D1 scRNA-seq ×2
HCC PBMC patient A-12 timepoint baseline scRN… ×2
Supports a case/control comparison: 31 samples read as cases, 4 as controls.
Read from the first 40 of 210 sample titles: 34 distinct titles with little repetition. Check it against the sample list below before relying on it.
Samples in this study
0 selected
- GSM9371441 HCC PBMC patient A-07 timepoint C2D1 scRNA-seq replicate 1
- GSM9371442 HCC PBMC patient B-23 timepoint C3D1 scRNA-seq
- GSM9371443 HCC PBMC patient B-21 timepoint C1D1 scRNA-seq
- GSM9371444 HCC PBMC patient B-10 timepoint C2D1 scRNA-seq
- GSM9371445 HCC PBMC patient B-03 timepoint C1D1 scRNA-seq
- GSM9371446 HCC PBMC patient B-22 timepoint C3D1 scRNA-seq
- GSM9371447 HCC PBMC patient A-04 timepoint C2D1 scRNA-seq replicate 1
- GSM9371448 PBMC healthy donor scRNA-seq replicate 1-1
- GSM9371449 HCC PBMC patient A-32 timepoint C1D1 scRNA-seq
- GSM9371450 HCC PBMC patient A-12 timepoint baseline scRNA-seq replicate 1
- GSM9371451 HCC PBMC patient A-04 timepoint C2D1 scRNA-seq replicate 2
- GSM9371452 HCC PBMC patient B-17 timepoint C1D1 scRNA-seq
- GSM9371453 HCC PBMC patient B-12 timepoint C2D1 scRNA-seq
- GSM9371454 HCC PBMC patient B-22 timepoint C2D15 scRNA-seq
- GSM9371455 HCC PBMC patient B-08 timepoint C1D1 scRNA-seq
- GSM9371456 PBMC healthy donor scRNA-seq replicate 1-3
- GSM9371457 HCC PBMC patient B-13 timepoint C2D1 scRNA-seq
- GSM9371458 HCC PBMC patient B-02 timepoint C1D1 scRNA-seq
- GSM9371459 HCC PBMC patient A-08 timepoint C1D1 scRNA-seq replicate 1
- GSM9371460 HCC PBMC patient A-12 timepoint baseline scRNA-seq replicate 2
- GSM9371461 HCC PBMC patient B-09 timepoint baseline scRNA-seq
- GSM9371462 HCC PBMC patient A-21 timepoint baseline scRNA-seq
- GSM9371463 HCC PBMC patient A-07 timepoint C2D1 scRNA-seq replicate 2
- GSM9371464 HCC PBMC patient B-03 timepoint C7D1 scRNA-seq
- GSM9371465 HCC PBMC patient B-23 timepoint C1D15 scRNA-seq
- GSM9371466 HCC PBMC patient B-05 timepoint C1D1 scRNA-seq
- GSM9371467 HCC PBMC patient B-14 timepoint C2D1 scRNA-seq replicate 1
- GSM9371468 HCC PBMC patient A-05 timepoint C4D1 scRNA-seq replicate 1
- GSM9371469 PBMC healthy donor scRNA-seq replicate 1-5
- GSM9371470 HCC PBMC patient A-30 timepoint C1D1 scRNA-seq replicate 1
- GSM9371471 HCC PBMC patient B-10 timepoint C1D1 scRNA-seq
- GSM9371472 HCC PBMC patient B-17 timepoint C2D1 scRNA-seq
- GSM9371473 HCC PBMC patient B-11 timepoint baseline scRNA-seq replicate 1
- GSM9371474 HCC PBMC patient B-17 timepoint Safety follow up scRNA-seq
- GSM9371475 HCC PBMC patient B-12 timepoint C1D1 scRNA-seq
- GSM9371476 HCC PBMC patient B-06 timepoint C1D1 scRNA-seq
- GSM9371477 HCC PBMC patient B-02 timepoint C2D1 scRNA-seq
- GSM9371478 HCC PBMC patient B-08 timepoint C7D1 scRNA-seq
- GSM9371479 PBMC healthy donor scRNA-seq replicate 1-6
- GSM9371480 HCC PBMC patient A-02 timepoint C1D1 scRNA-seq
+ 170 more — browse all 210 samples with per-sample file links →
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