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Spatially resolved atlas of IPF fibroblastic foci identifies that PAK2 kinase activation is involved in fibrogenesis

GSE285246 Homo sapiens Expression profiling by high throughput sequencing; Other 12 samples Submitted 2025/08/11 Platform GPL28038Platform GPL20795
Summary
Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease characterized by progressive fibrosis of the lung parenchyma. To identify potential therapeutic targets for IPF, we conducted spatial transcriptomic analysis and single-cell RNA sequencing (scRNA-seq). Our findings reveal that PAK plays a critical role in the immature fibroblast niche during fibrogenesis, highlighting its potential as a therapeutic target for the treatment of IPF.
Published in
Integrated spatial and single-cell transcriptomics reveal PAK kinase as a therapeutic target in fibroblastic foci and dense fibrosis of idiopathic pulmonary fibrosis
Watanabe N, Yoshida M, Hirano Y et al. · The European respiratory journal 2025 · PMID 40675771 · doi:10.1183/13993003.00022-2025
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Also filed as BioProject PRJNA1202105 and SRA study SRP553467. Searching any of these in the dataset finder brings you back here.

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