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High throughput sequencing of B and T cells in checkpoint inhibitor treated patients

GSE313597 Homo sapiens Expression profiling by high throughput sequencing; Other 27 samples Submitted 2026/05/01 Platform GPL30173
Summary
This is a prospective longitudinal study designed to identify biomarkers predictive of the onset of irAEs associated with ICI therapy and determine whether these biomarkers are further related to treatment efficacy. We obtained serial blood samples in patients who will be receiving anti-PD-1/PD-L1 either as a single agent or in combination with other therapy.
This dataset
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Direct links to NCBI, no account and no request form: the whole study as GSE313597_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 27 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1380378 and SRA study SRP654804. Searching any of these in the dataset finder brings you back here.

Study design
9 conditions, mostly in triplicate
GEX pool 1 channel ×3 GEX pool 2 channel ×3 GEX pool 3 channel ×3 TCR pool 1 channel ×3 TCR pool 2 channel ×3 TCR pool 3 channel ×3 FB pool 1 channel ×3 FB pool 2 channel ×3 +1 more

Supports a between-group comparison across 27 samples.

9 replicated groups read from 27 sample titles; they account for 27 of them. Check it against the sample list below before relying on it.

Samples in this study
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