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Biomarker-guided responses in patient-derived organoids predict effective therapies in breast cancer

GSE303509 Homo sapiens Expression profiling by high throughput sequencing 14 samples Submitted 2026/07/08 Platform GPL24676Platform GPL34284
Summary
Poor therapeutic response in subsets of breast cancer (BC) patients poses an ongoing challenge. Here, we present a series of 14 patient-derived triple-negative BC organoids, established with the aim of modeling resistant disease with greater fidelity using biomarkers and developing an in-vitro system grounded in clinical data for testing alternative treatment strategies.
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Direct links to NCBI, no account and no request form: the whole study as GSE303509_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 14 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1295546 and SRA study SRP603073. Searching any of these in the dataset finder brings you back here.

Study design
14 × patient-derived organoids, sample TORG

Supports a between-group comparison across 14 samples.

1 replicated groups read from 14 sample titles; they account for 14 of them. Check it against the sample list below before relying on it.

Samples in this study
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