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A single-cell atlas of immune heterogeneity in anti-PD1-treated non-small cell lung cancer

GSE243013 Homo sapiens Expression profiling by high throughput sequencing 243 samples Submitted 2025/01/28 Platform GPL24676
Summary
Anti-PD(L)1 with chemotherapy is a standard of care for non-small cell lung cancer (NSCLC), but a varying degree of response to the same regimen is observed in patients. The tumor immune microenvironment (TIME) plays a key role in response to immunotherapy, and the TIME heterogeneity in association with therapeutic outcome is incompletely understood. Here we prospectively applied single-cell RNA and TCR sequencing to characterize post-neoadjuvant chemo-immunotherapy treatment tumor samples of 234 NSCLC patients. Our study provides a fine-grained dissection of the TIME heterogeneity underlying response to chemo-immunotherapy in NSCLC, thus representing a valuable resource for improved management of NSCLC.
Published in
A single-cell atlas reveals immune heterogeneity in anti-PD-1-treated non-small cell lung cancer
Liu Z, Yang Z, Wu J et al. · Cell 2025 · PMID 40147443 · doi:10.1016/j.cell.2025.03.018
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Direct links to NCBI, no account and no request form: the whole study as GSE243013_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 243 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1015724. Searching any of these in the dataset finder brings you back here.

Study design
A cohort of 243 individual samples

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Sample titles run P1 … P68 and carry no group information.

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