GEO series
Single-nucleus RNA-sequencing (snRNA-seq) analysis of normal lung tissues, precursor lung lesions and invasive lung adenocarcinomas
GSE308103
Homo sapiens
Expression profiling by high throughput sequencing
75 samples
Submitted 2025/10/11
Platform GPL24676
Summary
Understanding cellular processes underlying early lung adenocarcinoma (LUAD) development is needed to devise intervention strategies. Here, we performed snRNA-seq analysis of human treatment-naive lungs comprising various stages in the sequence of pathogenesis of LUAD including normal lung tissues, atypical adenomatous hyperplasia (AAH), adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma (MIA) and LUAD.
Published in
Peng F, Sinjab A, Dai Y et al.
· Cancer cell 2026
· PMID 41202811
· doi:10.1016/j.ccell.2025.10.004
This dataset
Download
Direct links to NCBI, no account and no request form: the whole study as GSE308103_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 75 samples. Raw sequencing reads are also available from ENA.
Also filed as BioProject PRJNA1328749. Searching any of these in the dataset finder brings you back here.
Study design
40 conditions, each sampled once — no replicated groups
Read from the first 40 of 75 sample titles: 40 distinct titles with little repetition. Check it against the sample list below before relying on it.
Samples in this study
0 selected
- GSM9237901 Normal lung tissue of patient 3 [snRNA-seq]
- GSM9237902 Lung tissue with AIS of patient 3 [snRNA-seq]
- GSM9237903 Lung tissue with LUAD of patient 3 [snRNA-seq]
- GSM9237904 Normal lung tissue of patient 4 [snRNA-seq]
- GSM9237905 Second normal lung tissue of patient 4 [snRNA-seq]
- GSM9237906 Lung tissue with AAH of patient 4 [snRNA-seq]
- GSM9237907 Lung tissue with second AAH of patient 4 [snRNA-seq]
- GSM9237908 Lung tissue with LUAD of patient 4 [snRNA-seq]
- GSM9237909 Normal lung tissue of patient 5 [snRNA-seq]
- GSM9237910 Lung tissue with AIS of patient 5 [snRNA-seq]
- GSM9237911 Lung tissue with LUAD of patient 5 [snRNA-seq]
- GSM9237912 Normal lung tissue of patient 6 [snRNA-seq]
- GSM9237913 Lung tissue with AAH of patient 6 [snRNA-seq]
- GSM9237914 Lung tissue with LUAD of patient 6 [snRNA-seq]
- GSM9237915 Normal lung tissue of patient 7 [snRNA-seq]
- GSM9237916 Lung tissue with LUAD of patient 7 [snRNA-seq]
- GSM9237917 Lung tissue with second LUAD of patient 7 [snRNA-seq]
- GSM9237918 Normal lung tissue of patient 8 [snRNA-seq]
- GSM9237919 Lung tissue with AIS of patient 8 [snRNA-seq]
- GSM9237920 Lung tissue with LUAD of patient 8 [snRNA-seq]
- GSM9237921 Normal lung tissue of patient 9 [snRNA-seq]
- GSM9237922 Lung tissue with AAH of patient 9 [snRNA-seq]
- GSM9237923 Lung tissue with AIS of patient 9 [snRNA-seq]
- GSM9237924 Lung tissue with LUAD of patient 9 [snRNA-seq]
- GSM9237925 Normal lung tissue of patient 10 [snRNA-seq]
- GSM9237926 Lung tissue with MIA of patient 10 [snRNA-seq]
- GSM9237927 Lung tissue with LUAD of patient 10 [snRNA-seq]
- GSM9237928 Normal lung tissue of patient 11 [snRNA-seq]
- GSM9237929 Lung tissue with AAH of patient 11 [snRNA-seq]
- GSM9237930 Lung tissue with LUAD of patient 11 [snRNA-seq]
- GSM9237931 Normal lung tissue of patient 12 [snRNA-seq]
- GSM9237932 Lung tissue with AIS of patient 12 [snRNA-seq]
- GSM9237933 Lung tissue with LUAD of patient 12 [snRNA-seq]
- GSM9237934 Normal lung tissue of patient 13 [snRNA-seq]
- GSM9237935 Lung tissue with MIA of patient 13 [snRNA-seq]
- GSM9237936 Lung tissue with LUAD of patient 13 [snRNA-seq]
- GSM9237937 Normal lung tissue of patient 14 [snRNA-seq]
- GSM9237938 Lung tissue with AIS of patient 14 [snRNA-seq]
- GSM9237939 Lung tissue with LUAD of patient 14 [snRNA-seq]
- GSM9237940 Normal lung tissue of patient 15 [snRNA-seq]
+ 35 more — browse all 75 samples with per-sample file links →
Similar datasets
- GSE243013 A single-cell atlas of immune heterogeneity in anti-PD1-treated non-small cell lung cancer 243 samples
- GSE269877 Single-cell RNA-sequencing of BCG naïve and recurrent non-muscle invasive bladder cancer reveals a CD6/ALCAM-mediated immune-suppressive pathway 38 samples
- GSE294300 Single-cell gene expression profiles of cells from primary colorectal cancer and adjacent normal tissue [scRNA-Seq] 36 samples
- GSE271107 Single-cell RNA sequencing of bone marrow aspirate samples from multiple myeloma and its precursor conditions 19 samples
- GSE263733 Single-cell transcriptome analysis reveals subtype-specific clonal evolution and microenvironmental changes in liver metastasis of pancreatic adenocarcinoma and their clinical implications 218 samples
- GSE282122 A longitudinal single-cell atlas of anti-tumour necrosis factor treatment in inflammatory bowel disease 216 samples
- GSE328048 Single-cell transcriptome reveals keratinocyte subclusters that contribute to altered differentiation and inflammatory responses in atopic dermatitis 116 samples
- GSE327167 Single-cell RNA-seq profiling of pleural mesothelioma and comparator pleural specimens 113 samples
Share this dataset
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.