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Persistent dopamine-dependent remodeling of the neural transcriptome in response to pregnancy and postpartum

GSE298544 Homo sapiens; Mus musculus Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing 397 samples Submitted 2026/04/01 Platform GPL34328Platform GPL24247Platform GPL34281Platform GPL34284Platform GPL34290
SuperSeries — this record groups several sub-series.
Summary
This SuperSeries is composed of the SubSeries listed below.
Published in
Dopamine drives persistent remodelling of the maternal brain
O'Chan JC, Di Salvo G, Cunningham AM et al. · Nature 2026 · PMID 42162419 · doi:10.1038/s41586-026-10509-4
This dataset
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Direct links to NCBI, no account and no request form: the whole study as GSE298544_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 397 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1269798 and SRA study SRP565039. Searching any of these in the dataset finder brings you back here.

Study design
14 × dHipp vs 13 × mPFC vs 13 × vHipp

Supports a between-group comparison across 40 samples.

3 replicated groups read from the first 40 of 397 sample titles; they account for 40 of them. Check it against the sample list below before relying on it.

Samples in this study

+ 357 more — browse all 397 samples with per-sample file links →

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