← BioTransfer GEO Dataset Finder
GEO series

Bidirectional histone monoaminylation dynamics regulate neural rhythmicity

GSE270434 Homo sapiens; Mus musculus Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing 234 samples Submitted 2024/10/10 Platform GPL34290Platform GPL24676Platform GPL24247
SuperSeries — this record groups several sub-series.
Summary
This SuperSeries is composed of the SubSeries listed below.
Published in
Bidirectional histone monoaminylation dynamics regulate neural rhythmicity
Zheng Q, Weekley BH, Vinson DA et al. · Nature 2025 · PMID 39779849 · doi:10.1038/s41586-024-08371-3
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE270434_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 234 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1126622 and SRA study SRP515226. Searching any of these in the dataset finder brings you back here.

Study design
9 conditions, mostly with about 4 replicates each
RNAseq_ZT4_GFP_Cohort1 ×5 RNAseq_ZT8_GFP_Cohort1 ×5 RNAseq_ZT0_GFP_Cohort1 ×4 RNAseq_ZT0_H3.3_Cohort1 ×4 RNAseq_ZT0_Q5A_Cohort1 ×4 RNAseq_ZT4_H3.3_Cohort1 ×4 RNAseq_ZT4_Q5A_Cohort1 ×4 RNAseq_ZT4_Q5A_Cohort2 ×3 +6 more

Supports a between-group comparison across 35 samples.

9 replicated groups read from the first 40 of 234 sample titles; they account for 35 of them. Check it against the sample list below before relying on it.

Samples in this study

+ 194 more — browse all 234 samples with per-sample file links →

Similar datasets

Search all RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.