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The remodeling of bivalent chromatin is essential for mouse peri-implantation embryogenesis.

GSE274495 Homo sapiens; Mus musculus Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing 421 samples Submitted 2025/07/23 Platform GPL24676Platform GPL24247
SuperSeries — this record groups several sub-series.
Summary
This SuperSeries is composed of the SubSeries listed below.
Published in
Remodelling bivalent chromatin is essential for mouse peri-implantation embryogenesis
Li Y, He J, Liu Y et al. · Nature cell biology 2025 · PMID 41034520 · doi:10.1038/s41556-025-01776-w
This dataset
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Direct links to NCBI, no account and no request form: the whole study as GSE274495_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 421 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1146730 and SRA study SRP525583. Searching any of these in the dataset finder brings you back here.

Study design
14 conditions, mostly in triplicate
WT_RNA-Epi-4.5 ×3 WT_RNA-Epi-4.75 ×3 WT_RNA-Epi-5.0_invivo ×3 WT_RNA-Epi-5.0 ×3 WT_RNA-Epi-5.25_invivo ×3 WT_RNA-Epi-5.25 ×3 WT_RNA-Epi-5.5_invitro ×3 WT_RNA-ExE-4.75 ×3 +6 more

Supports a between-group comparison across 40 samples.

14 replicated groups read from the first 40 of 421 sample titles; they account for 40 of them. Check it against the sample list below before relying on it.

Samples in this study

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