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Unbalanced chromatin binding of Polycomb complexes drives neurodevelopmental disorders

GSE312574 Homo sapiens; Mus musculus Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing 179 samples Submitted 2026/02/17 Platform GPL24247Platform GPL34290Platform GPL34284
SuperSeries — this record groups several sub-series.
Summary
This SuperSeries is composed of the SubSeries listed below.
Published in
Unbalanced chromatin binding of Polycomb complexes drives neurodevelopmental disorders
Borges RL, González-Blanco G, Arigela H et al. · Molecular cell 2026 · PMID 41653922 · doi:10.1016/j.molcel.2026.01.023
This dataset
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Direct links to NCBI, no account and no request form: the whole study as GSE312574_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 179 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1374195 and SRA study SRP556323. Searching any of these in the dataset finder brings you back here.

Study design
19 conditions, mostly in duplicate
mESC ,Clone R70H 112 , ×2 mESC ,Clone R70H 282 , ×2 mESC ,WT , ×2 mNPC ,Clone R70H 112 , ×2 mNPC ,Clone R70H 282 , ×2 mNPC ,WT , ×2 mNeuronDiff ,Clone R70H 112 , ×2 mNeuronDiff ,Clone R70H 282 , ×2 +13 more

Supports a between-group comparison across 38 samples.

19 replicated groups read from the first 40 of 179 sample titles; they account for 38 of them. Check it against the sample list below before relying on it.

Samples in this study

+ 139 more — browse all 179 samples with per-sample file links →

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