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FOXA2/AP-1 drives prostate cancer lineage plasticity

GSE232555 Homo sapiens; Mus musculus Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing 101 samples Submitted 2024/04/22 Platform GPL18573Platform GPL30172Platform GPL30173
SuperSeries — this record groups several sub-series.
Summary
This SuperSeries is composed of the SubSeries listed below.
Published in
FOXA2 rewires AP-1 for transcriptional reprogramming and lineage plasticity in prostate cancer
Wang Z, Townley SL, Zhang S et al. · Nature communications 2024 · PMID 38851846 · doi:10.1038/s41467-024-49234-9
This dataset
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Direct links to NCBI, no account and no request form: the whole study as GSE232555_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 101 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA972713 and SRA study SRP437782. Searching any of these in the dataset finder brings you back here.

Study design
7 conditions, mostly in duplicate
PDX201.1, vehicle, ChIP-FOXA1, repeat ×4 PDX201.2, vehicle, ChIP-FOXA2, repeat ×4 PDX201.1, vehicle, ChIP-H3K27Ac, repeat ×3 LNCaP_CTL_cells,vehicle, repeat ×3 PDX201.1, vehicle, ChIP-AR, repeat ×2 PDX201.2, vehicle, ChIP-H3K27Ac, repeat ×2 LNCaP_FOXA2OE, vehicle, repeat ×2 NCI-H660 cells, ORY-1001, ChIP-FOXA ×1 +19 more

Supports a between-group comparison across 20 samples.

7 replicated groups read from the first 40 of 101 sample titles; they account for 20 of them. Check it against the sample list below before relying on it.

Samples in this study

+ 61 more — browse all 101 samples with per-sample file links →

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