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RNA-seq of Mouse Spinal Cord after Lateral Compression Spinal Cord Injury followed by Delayed Atorvastatin or Vehicle Treatment [Bulk RNA-seq of mice spinal cords]

GSE271662 Mus musculus Expression profiling by high throughput sequencing 16 samples Submitted 2025/01/05 Platform GPL24247
Summary
This dataset supports a study investigating the effects of delayed atorvastatin treatment on gene expression and functional recovery in a chronic mouse model of spinal cord injury (SCI). Twelve-week-old female C57BL/6 mice were subjected to moderate 0.25 mm lateral compression SCI and after two weeks, were treated with atorvastatin (10 mg/kg) or a vehicle control daily for four weeks. Bulk RNA sequencing of spinal cord tissues at six weeks post-injury revealed broad alterations to gene expression due to SCI (DEGs common to both treatments and unique to each) and a smaller set of alterations due uniquely to atorvastatin treatment. Atorvastatin treatment specifically activated gene programs associated with axon guidance and fatty acid transport, which may contribute to the enhanced sensorimotor recovery. This RNA-seq dataset offers insights into the molecular underpinnings by which atorvastatin enhances sensorimotor recovery and modulates gene expression post-SCI.
Published in
Delayed atorvastatin delivery promotes recovery after experimental spinal cord injury
Buchl SC, Kim HN, Hur B et al. · Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2025 · PMID 39755500 · doi:10.1016/j.neurot.2024.e00517
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Direct links to NCBI, no account and no request form: the whole study as GSE271662_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 16 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1132719 and SRA study SRP518382. Searching any of these in the dataset finder brings you back here.

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