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Bulk RNA-Seq from kidneys of uninephrectomized db/db mice as a model of severe diabetic kidney disease

GSE228960 Mus musculus Expression profiling by high throughput sequencing 28 samples Submitted 2025/04/01 Platform GPL24247
Summary
This dataset utilized uninephrectomized db/db mice and db/m mice as a control for comparison. We performed bulk RNA-seq studies at two time points (26 and 35 weeks of age) to identify the mechanism of severity of diabetic kidney disease.
Published in
Renal transcriptome analysis of uninephrectomized db/db mice identified a mechanism for the transition to severe diabetic nephropathy
Maekawa M, Maekawa T, Sasase T et al. · Experimental animals 2024 · PMID 37482420 · doi:10.1538/expanim.22-0168
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Direct links to NCBI, no account and no request form: the whole study as GSE228960_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 28 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA952248 and SRA study SRP430882. Searching any of these in the dataset finder brings you back here.

Study design
12 × db/db, 26w, vs 6 × db/m, 35w, vs 5 × db/m, 26w, vs 5 × db/db, 35w,

Supports a between-group comparison across 28 samples.

4 replicated groups read from 28 sample titles; they account for 28 of them. Check it against the sample list below before relying on it.

Samples in this study
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