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Transcriptome Analysis Reveals Gene Expression Changes in a mouse Model of Hyperoxia-induced acute lung injury

GSE237260 Mus musculus Expression profiling by high throughput sequencing 12 samples Submitted 2024/04/05 Platform GPL24247
Summary
Oxygen therapy is essential for cure critically patients in ICU, but hyperoxia can cause damage to many organs, including the lungs, leading to Hyperoxia Acute Lung Injury (HALI), a mild type of acute respiratory distress syndrome (ARDS). However, the comprehensive pathogenesis and regulation mechanisms underlying the development of HALI remain unclear. In this study, we conducted a mouse model with hyperoxia treatment and sequenced the gene expression pattern of HALI-mice and relative control (RNA-seq).
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Direct links to NCBI, no account and no request form: the whole study as GSE237260_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 12 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA994486 and SRA study SRP449315. Searching any of these in the dataset finder brings you back here.

Study design
6 × mouse model for HALI, vs 6 × wild type mose,

Supports a between-group comparison across 12 samples.

2 replicated groups read from 12 sample titles; they account for 12 of them. Check it against the sample list below before relying on it.

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