GEO series

Role of HIV-1 in IL-8 response of human stellate cells to gram-positive microbial products

GSE324653 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing 11 samples Submitted 2026/03/13 Platform GPL34281

Summary

Patients living with Human Immunodeficiency Virus (PLWH) develop accelerated liver fibrosis, but the exact mechanism remains unknown. Unlike gram-negative bacterial products, the impact of gram-positive microbial products in Human Immunodeficiency Virus 1 (HIV-1) associated liver inflammation and fibrosis remains poorly understood. In this study, we investigated the effect of lipoteichoic acid (LTA), a major gram-positive bacterial component, on HSCs in the context of HIV-1 infection. Our data revealed that HIV-1 infection sensitizes HSCs to LTA stimulation, leading to an amplified IL-8 response mediated through histone acetylation that may accelerate liver fibrosis progression in PLWH. As microbial translocation persists despite effective antiretroviral therapy, these findings underscore the need for targeted strategies to mitigate liver fibrosis in HIV-1 infected patients.

Published in

Ali RO, Zhang L, Chamroonkul N et al. · Scientific reports 2026 · PMID 42297971 · doi:10.1038/s41598-026-56186-1

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Direct links to NCBI, no account and no request form: the whole study as GSE324653_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 11 samples. Raw sequencing reads are also available from ENA.

Whole study · RAW.tar ↓ Series matrix ↓ All supplementary files ↗ Raw reads on ENA ↗

Also filed as BioProject PRJNA1436502 and SRA study SRP683160. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 42297971) ↗

Study design

3 × Lx2 cells, PBS treatment for 24hrs,Repeat vs 3 × Lx2 cells, HIV-1-Bal infetion for 24hrs,Repeat vs 3 × Lx2 cells, HIV-1-Bal infetion with LTA stimulation for 24hrs,Repeat

Supports a between-group comparison across 9 samples.

3 replicated groups read from 11 sample titles; they account for 9 of them. Check it against the sample list below before relying on it.

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