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Epigenetic Regulation of Non-canonical Menin Targets Modulates Menin Inhibitor Response in Acute Myeloid Leukemia

GSE249080 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing 40 samples Submitted 2024/11/20 Platform GPL24676Platform GPL20301
SuperSeries — this record groups several sub-series.
Summary
This SuperSeries is composed of the SubSeries listed below.
Published in
Epigenetic regulation of noncanonical menin targets modulates menin inhibitor response in acute myeloid leukemia
Zhou X, Zhang L, Aryal S et al. · Blood 2024 · PMID 39158067 · doi:10.1182/blood.2023023644
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Direct links to NCBI, no account and no request form: the whole study as GSE249080_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 40 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1047121 and SRA study SRP475183. Searching any of these in the dataset finder brings you back here.

Study design
14 conditions, mostly in duplicate
AML2_sgLuc_DMSO_control ×2 AML2_sgLuc_VTP50469 ×2 AML2_sgPCGF1_8_DMSO ×2 AML2_sgPCGF1_8_VTP50469 ×2 AML2_sgBCOR_7_DMSO ×2 AML2_sgBCOR_7_VTP50469 ×2 MV411_sgLuc_DMSO ×2 MV411_sgLuc_VTP50469 ×2 +18 more

Supports a between-group comparison across 28 samples.

14 replicated groups read from 40 sample titles; they account for 28 of them. Check it against the sample list below before relying on it.

Samples in this study
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