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Genome-wide CRISPR screen identifies Menin and SUZ12 as regulators of human developmental timing.

GSE279036 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing 102 samples Submitted 2025/06/26 Platform GPL24676
SuperSeries — this record groups several sub-series.
Summary
This SuperSeries is composed of the SubSeries listed below.
Published in
Genome-wide CRISPR screen identifies Menin and SUZ12 as regulators of human developmental timing
Xu N, Cho HS, Hackland JOS et al. · Nature cell biology 2025 · PMID 40897805 · doi:10.1038/s41556-025-01751-5
This dataset
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Direct links to NCBI, no account and no request form: the whole study as GSE279036_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 102 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1170206 and SRA study SRP537152. Searching any of these in the dataset finder brings you back here.

Study design
19 conditions, mostly in duplicate
NT_d0_set1_RNA-seq ×3 NT_d1_set1_RNA-seq ×3 NT_d0_ATAC-seq ×2 MEN1_1_d0_ATAC-seq ×2 MEN1_2_d0_ATAC-seq ×2 SUZ12_1_d0_ATAC-seq ×2 SUZ12_2_d0_ATAC-seq ×2 NT_d2_set1_RNA-seq ×2 +11 more

Supports a between-group comparison across 40 samples.

19 replicated groups read from the first 40 of 102 sample titles; they account for 40 of them. Check it against the sample list below before relying on it.

Samples in this study

+ 62 more — browse all 102 samples with per-sample file links →

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