Integrative multi-omics identifies AP-1 transcription factor as a targetable mediator of acquired osimertinib resistance in non-small cell lung cancer
Direct links to NCBI, no account and no request form: the whole study as GSE295823_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 20 samples. Raw sequencing reads are also available from ENA.
Also filed as BioProject PRJNA1256437 and SRA study SRP535260. Searching any of these in the dataset finder brings you back here.
Supports a case/control comparison: 10 samples read as cases, 5 as controls.
7 replicated groups read from 20 sample titles; they account for 20 of them. Check it against the sample list below before relying on it.
- GSM8542207 HCC827 cells, control, replicate 1
- GSM8542208 HCC827 cells, control, replicate 2
- GSM8542209 Resistant HCC827 cells, (HCC827-OsiR), replicate 1
- GSM8542210 Resistant HCC827 cells, (HCC827-OsiR), replicate 2
- GSM8542211 HCC827 cells, control, replicate 1
- GSM8542212 HCC827 cells, control, replicate 2
- GSM8542213 HCC827 cells, control, replicate 3
- GSM8542214 Resistant HCC827 cells, (HCC827-OsiR), replicate 1
- GSM8542215 Resistant HCC827 cells, (HCC827-OsiR), replicate 2
- GSM8542216 Resistant HCC827 cells, (HCC827-OsiR), replicate 3
- GSM8546035 Resistant HCC827 FOSL1 g1 knockout cells, (HCC827-OsiR FOSL1 g1 KO), replicate 1
- GSM8546036 Resistant HCC827 FOSL1 g1 knockout cells, (HCC827-OsiR FOSL1 g1 KO), replicate 2
- GSM8546037 Resistant HCC827 FOSL1 g2 knockout cells, (HCC827-OsiR FOSL1 g1 KO), replicate 1
- GSM8546038 Resistant HCC827 FOSL1 g2 knockout cells, (HCC827-OsiR FOSL1 g1 KO), replicate 2
- GSM8546039 Resistant HCC827 JUN g1 knockout cells, (HCC827-OsiR JUN g1 KO), replicate 1
- GSM8546040 Resistant HCC827 JUN g1 knockout cells, (HCC827-OsiR JUN g1 KO), replicate 2
- GSM8546041 Resistant HCC827 JUN g2 knockout cells, (HCC827-OsiR JUN g1 KO), replicate 1
- GSM8546042 Resistant HCC827 JUN g2 knockout cells, (HCC827-OsiR JUN g1 KO), replicate 2
- GSM8546043 Resistant HCC827 Renilla knockout cells, (HCC827-OsiR Ren KO), replicate 1
- GSM8546044 Resistant HCC827 Renilla knockout cells, (HCC827-OsiR Ren KO), replicate 2
- GSE335210 SOX9-BAF multi-omics profiling in human colon cancer cell models 173 samples
- GSE237810 Multi-omics analysis of FOXO3 pioneer factor activity reveals distinct networks in proliferating and DNA damage induced senescent cells 65 samples
- GSE330130 A multi-omics characterization of the human lumbar spinal cord and motor cortex reveals non-overlapping molecular signatures in ALS [snRNA-Seq; snATAC-Seq] 87 samples
- GSE294559 Single-cell multi-omics characterize colorectal tumors, adjacent healthy tissue and matched organoids identifying CRC-unique features 72 samples
- GSE227974 MY-COMP, an inhibitor of the transcriptional activity of YAP-B-MYB, identifies NEK2 as a novel mediator of YAP oncogenesis in uveal melanoma cells 29 samples
- GSE304741 Cytotoxic CD39+ tumor-associated NK cells respond to NKG2A blockade in lung cancer (10X Multiome) 22 samples
- GSE254297 Integrated multi-omics analysis 10 samples
- GSE309697 Generation of a Comprehensive Epigenomic Atlas in Clear Cell Renal Cell Carcinoma Informs Kidney Cancer Progression and Heritability 265 samples
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.