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Multi-omics analysis of FOXO3 pioneer factor activity reveals distinct networks in proliferating and DNA damage induced senescent cells

GSE237810 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing 65 samples Submitted 2026/07/24 Platform GPL16791
SuperSeries — this record groups several sub-series.
Summary
This SuperSeries is composed of the SubSeries listed below.
This dataset
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Direct links to NCBI, no account and no request form: the whole study as GSE237810_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 65 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA996654 and SRA study SRP450413. Searching any of these in the dataset finder brings you back here.

Study design
13 conditions, mostly in triplicate
U87MG cells, FOXO3 Act.8hrs, ×3 U87MG cells, FOXO3 Act.16hrs, ×3 U87MG cells, GFP control, ×3 U87MG cells, GFP control w PFI3, ×3 U87MG, FOXO3 Act.8hrs w PFI3, ×3 U87MG, FOXO3 Act.16hrs w PFI3, ×3 U87MG cells, 3d Etoposide, ×3 U87MG cells, 14d Etoposide, ×3 +6 more

Supports a between-group comparison across 39 samples.

13 replicated groups read from the first 40 of 65 sample titles; they account for 39 of them. Check it against the sample list below before relying on it.

Samples in this study

+ 25 more — browse all 65 samples with per-sample file links →

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