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The role of RUNX2 and BHLHE40 in pathologically relevant CD4-positive tissue-resident T-cells in Crohn's disease. (scMultiome)

GSE280714 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing 12 samples Submitted 2025/08/14 Platform GPL24676
Summary
Tissue-resident T-cells (TRM) are deeply involved in immune memory at the site of inflammation. Here, we identified two key transcription factors, RUNX2 and BHLHE40 as regulators of pathologically relevant CD4-positive TRM in the inflamed gut mucosa of Crohn’s disease patients.
Published in
Multi-omics uncovers transcriptional programs of gut-resident memory CD4+ T cells in Crohn's disease
Arase M, Murakami M, Kihara T et al. · The Journal of experimental medicine 2025 · PMID 40906156 · doi:10.1084/jem.20242106
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Direct links to NCBI, no account and no request form: the whole study as GSE280714_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 12 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1180087 and SRA study SRP542210. Searching any of these in the dataset finder brings you back here.

Study design
12 conditions, each sampled once — no replicated groups

Read from 12 sample titles: 12 distinct titles with little repetition. Check it against the sample list below before relying on it.

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